Protein Info for Ac3H11_1857 in Acidovorax sp. GW101-3H11

Annotation: Magnesium and cobalt efflux protein CorC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 291 PF00571: CBS" amino acids 74 to 124 (51 residues), 26.3 bits, see alignment 7.7e-10 amino acids 137 to 186 (50 residues), 31.1 bits, see alignment 2.4e-11 PF03471: CorC_HlyC" amino acids 206 to 283 (78 residues), 56.9 bits, see alignment E=1.7e-19

Best Hits

KEGG orthology group: K06189, magnesium and cobalt transporter (inferred from 83% identity to dac:Daci_1271)

Predicted SEED Role

"Magnesium and cobalt efflux protein CorC" in subsystem Copper homeostasis: copper tolerance or Phosphate metabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165KJV3 at UniProt or InterPro

Protein Sequence (291 amino acids)

>Ac3H11_1857 Magnesium and cobalt efflux protein CorC (Acidovorax sp. GW101-3H11)
VSDPHPGRPPEKEDKRTFLQKVAEFIHPGPDSTQELIETLAEAEDNQVIGAESRVMLERV
IRMADMTARDVMVATPRMDQVNIDAPFDELLHLVINTAHSRFPVYQGERDNIIGILMAKD
LLKLQRAPELNIRALLRPAVFVPESKGLNDLLREFRGNRNHLAIVIDEFGRMAGLVTIED
VLEQIVGEIEDEFDIPEDDGDIFGLADRTYRVSGDTSVERVCEAFDVLIQSSDPGESFDT
IGGLIAHEMGHVPKRGEQLLLGGLQFVVLHTKGGAVRWFKVSKAEDGSAAA