Protein Info for Ac3H11_167 in Acidovorax sp. GW101-3H11

Annotation: Glycine dehydrogenase [decarboxylating] (glycine cleavage system P protein) (EC 1.4.4.2)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 970 signal peptide" amino acids 1 to 18 (18 residues), see Phobius details TIGR00461: glycine dehydrogenase" amino acids 23 to 963 (941 residues), 1430.5 bits, see alignment E=0 PF02347: GDC-P" amino acids 23 to 449 (427 residues), 580.5 bits, see alignment E=2.2e-178 amino acids 468 to 743 (276 residues), 35.6 bits, see alignment E=5.3e-13 PF21478: GcvP2_C" amino acids 791 to 912 (122 residues), 193.6 bits, see alignment E=8.8e-62

Best Hits

KEGG orthology group: K00281, glycine dehydrogenase [EC: 1.4.4.2] (inferred from 84% identity to ajs:Ajs_1936)

Predicted SEED Role

"Glycine dehydrogenase [decarboxylating] (glycine cleavage system P protein) (EC 1.4.4.2)" in subsystem Glycine and Serine Utilization or Glycine cleavage system or Photorespiration (oxidative C2 cycle) (EC 1.4.4.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.4.4.2

Use Curated BLAST to search for 1.4.4.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165IXX1 at UniProt or InterPro

Protein Sequence (970 amino acids)

>Ac3H11_167 Glycine dehydrogenase [decarboxylating] (glycine cleavage system P protein) (EC 1.4.4.2) (Acidovorax sp. GW101-3H11)
MTAALPTSLPLSALENAAEFLPRHIGIDAADEAHMLSVIGEASRRTLIDSIVPRSIARSR
AMDLPAATTEAAALAELKAIAGKNKVLKSFIGQGYYGTHTPGVILRNILENPAWYTAYTP
YQAEISQGRMEALVNFQTMVCDLTGMPIANASMLDEATAAAEAMTLAKRSVKSKSNVFVV
AGDAHPQTIEVIQTRAKPLGLDVRLANSAEEWDSLLAGDYFAVLAQYPATSGRIDDLRAD
VEKAHAKQAAFIVAADLLALTLITPPGEQGADIVVGTTQRFGMPMGAGGPHAAFMACRDE
FKRSLPGRLVGVSVDVHGKPAYRLALQTREQHIRREKATSNICTAQVLPAVVASMYAVYH
GPEGLSRIAQRVASYTAILARGLVQLGAPVREQATFDTLVLKTDGATKSIATKAIQSGAN
LRIYFESYLCISLDETTTRADIELLWKVFAKDGQALPTFDAFENGVEPLIPAALRRTSRY
LTHPVFNTHHSETGMLRYIRQLSDKDLALDRSMIPLGSCTMKLNATSEMIPITWPEFANM
HPFAPADQQQGYKALDEQLRAWLCEATGYAGISLQPNAGSQGEYAGLLAIKGYHESRGEG
HRNICLIPSSAHGTNPASAQMVGMQVVVTACDANGNVDLADLQAKCEQHSGNIACVMITY
PSTHGVFETSVKELCALVHSHGGRVYVDGANMNALVGVAAPGEFGGDVSHLNLHKTFCIP
HGGGGPGVGPVCVVEDLVPFLPGLPGQGDQPKSPATGKVGPVSAAPLGNAAVLPISWMYI
RMMGADGLQAATETAILSANYISARLKDHYPTLYASENGHVAHECILDLRGLKDTSGVMA
EDVAKRLIDYGFHAPTLSFPVPNTLMVEPTESETLFEIDRFIDAMIAIREEIRQIEAGKL
PQDNNPLKNAPHTAENLLSGEWTRPYTREAAAYPVAALRQAKYWSPVGRVDNVWGDRNLS
CSCIPVSDYA