Protein Info for Ac3H11_1539 in Acidovorax sp. GW101-3H11

Annotation: UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 606 transmembrane" amino acids 12 to 33 (22 residues), see Phobius details amino acids 46 to 68 (23 residues), see Phobius details amino acids 83 to 103 (21 residues), see Phobius details amino acids 109 to 129 (21 residues), see Phobius details PF13727: CoA_binding_3" amino acids 77 to 213 (137 residues), 35.6 bits, see alignment E=3.9e-12 PF00106: adh_short" amino acids 279 to 436 (158 residues), 28 bits, see alignment E=6.1e-10 PF04321: RmlD_sub_bind" amino acids 280 to 460 (181 residues), 55.5 bits, see alignment E=2e-18 PF01370: Epimerase" amino acids 280 to 500 (221 residues), 77.9 bits, see alignment E=3.3e-25 PF02719: Polysacc_synt_2" amino acids 280 to 564 (285 residues), 382.6 bits, see alignment E=4.8e-118 PF16363: GDP_Man_Dehyd" amino acids 281 to 405 (125 residues), 42.5 bits, see alignment E=2.4e-14 PF01073: 3Beta_HSD" amino acids 281 to 411 (131 residues), 30.9 bits, see alignment E=6.1e-11 PF07993: NAD_binding_4" amino acids 352 to 411 (60 residues), 21.1 bits, see alignment 6e-08

Best Hits

KEGG orthology group: None (inferred from 66% identity to vei:Veis_4862)

Predicted SEED Role

"UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-)" in subsystem N-linked Glycosylation in Bacteria (EC 4.2.1.-)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.2.1.-

Use Curated BLAST to search for 4.2.1.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165KE92 at UniProt or InterPro

Protein Sequence (606 amino acids)

>Ac3H11_1539 UDP-N-acetylglucosamine 4,6-dehydratase (EC 4.2.1.-) (Acidovorax sp. GW101-3H11)
VLPNRTAVRLSSLVLLALDTALILLAWVLSFWLRFNLDVPDEFSSMAVESALLAVGSYWV
AFVGMGVHRQVWRYIGLSELRQLAIAVFLASLLTAAAVLMLRVPSFPRSVLLLHPLIVLM
LLVAARAAWRTLFERAVLPTGTRPILIVGALQDAADALRALKGSGHWHPVGIVSHLESEQ
GRSLQGVPVLGTTTNIDSIARSVDVRTALLASPAGSEGRSEVLKYSSDAGLALLAMPRPD
EWLRTESVGPRRIELEDLLGRVQVQLDAKGLSDLFAGTCVLVTGAGGSIGSELCRQIARF
GVARLVCVDVSEFAIYQLEQELREAHPQMQGMYYTANVREVERLHAIARLHQPTVVFHAA
AYKHVPLMESLNEIEALRTNVLGTMNVARVAAAIGAARFVLISTDKAVNPTNVMGASKRL
AERVMQAVASEHPGTRFVAVRFGNVLGSSGSVVPLFAEQIARGGPVTVTHPDIVRYFMTI
PEAAQLVLQAGLMGQSGQIFVLDMGEPVKIVELARILVRLSGKTEQEIPIVFTGLRPGEK
LYEELLANGETTEPTPHPKLHVAKTDASGGVNPEAVSQSIADLGVEPSASALRSWLQTQV
PEYTAR