Protein Info for Ac3H11_1196 in Acidovorax sp. GW101-3H11

Annotation: Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1191 transmembrane" amino acids 751 to 772 (22 residues), see Phobius details PF02775: TPP_enzyme_C" amino acids 483 to 635 (153 residues), 26.1 bits, see alignment E=9.8e-10 PF01558: POR" amino acids 760 to 947 (188 residues), 66 bits, see alignment E=7.4e-22 PF20169: DUF6537" amino acids 975 to 1172 (198 residues), 240.7 bits, see alignment E=2.2e-75

Best Hits

KEGG orthology group: K04090, indolepyruvate ferredoxin oxidoreductase [EC: 1.2.7.8] (inferred from 86% identity to aaa:Acav_4581)

Predicted SEED Role

"Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits" in subsystem Aromatic amino acid interconversions with aryl acids

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.7.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A165LBA4 at UniProt or InterPro

Protein Sequence (1191 amino acids)

>Ac3H11_1196 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits (Acidovorax sp. GW101-3H11)
MNAPLPESVRKALETVTLDDKYSLDHGRAFMSGVQALVRLPMLQRQRDAVAGLNTAGFIS
GYRGSPLGTYDQALWAAKKHLAANNIVFQPGVNEELGATAVWGTQQLDLYPQSKKFDGVF
GIWYGKGPGVDRCSDVFKHANMAGTAKHGGVIAIAGDDHISKSSTAAHQSDHIFKACGTP
VFFPSSVQEILDMGLHAFAMSRFSGVWSGMKTIQEVVESSSSINIDPDRVKIVMPEDFVM
PPGGLHIRWPDAPLEQEARLMDYKWYAALAYIRANKLNYNVIEGKNDRFGIIASGKAYND
TRQALVDLGLDDDTCRQLGIRVHKVNVVWPLEATITRDFAQGLQEILVVEEKRQVIEYQL
KEELYNWRADVRPNVLGKFDEPEGDATGGEWSMPNPSQNWLLRAKADLTPAIIAKAIAKR
LKKLGVSSDIIARMDSRIAVIEASERGMAELKVDTGERAPWFCSGCPHNTSTRVPEGSRA
VAGIGCHYMANWMPDRKTSTFTQMGGEGVTWVGQAPFTTDAHVFANLGDGTYFHSGLLAI
RQSIAAGTSITYKVLYNDAVAMTGGQTVGERPEGHSVLQIMNSLKSEGVVKLIIVTDEPQ
KYDGVALAAGVTVHHRDELDTLQRQFREIKGCTVIIYDQTCATEKRRRRKRGTLATPDKT
VVINDLVCEGCGDCSTKSNCLSVEPVETEFGRKRRINQSTCNKDYSCVNGFCPSFVTVEG
GKLKKPKKEKKGDLSALPSIPEPVLPVAEAAWGIVVGGVGGTGVITIGSLLGMAAHLDGK
GVITQDAGGLAQKGGATWSHIQIANRPEAIYTTKVDTAKADLVIGCDSIVAAHKYTLTVM
QPGRTFVALNTHSTPTAAFVTNPDWQFPGANCDSAIAAAVGAGGVGSFDAEQVATQLLGD
SIYTNPLMLGYAWQKGRVPLTLASLMRAMELNGVQVDNNKAAFEWGRRCAHDLASVQALF
QAAQVIQFVKKPSLTEMIAKRVEFLTGYQNAAYAAEYHAFVEKVKATESRLDVGTRLSEA
VARYLFKLMAYKDEYEVARLHTDKAFTDKIVNMFEGDYKLVHHLAPPMTAKKNDKGELVK
QPFGPWMRSAFGLLAKMKGLRGTALDVFGKTEERRMERALIVEYRACIDELLATLNADNL
ALAVEIARIPEEIRGYGHVKERHLKAARPKWDGLMAQWRSGKAAPGQRQAA