Protein Info for AZOBR_RS23555 in Azospirillum brasilense Sp245

Annotation: beta-lactamase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 296 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details PF00144: Beta-lactamase" amino acids 46 to 253 (208 residues), 128.5 bits, see alignment E=3.3e-41 PF13354: Beta-lactamase2" amino acids 51 to 261 (211 residues), 174.6 bits, see alignment E=1.9e-55

Best Hits

Swiss-Prot: 49% identical to BLC97_ECOLX: Beta-lactamase CTX-M-97 (bla) from Escherichia coli

KEGG orthology group: K01467, beta-lactamase [EC: 3.5.2.6] (inferred from 71% identity to azl:AZL_a02580)

MetaCyc: 38% identical to PSE-4 beta-lactamase (Pseudomonas aeruginosa)
Beta-lactamase. [EC: 3.5.2.6]

Predicted SEED Role

"Beta-lactamase (EC 3.5.2.6)" in subsystem Beta-lactamase or Tn552 (EC 3.5.2.6)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.2.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8AUN0 at UniProt or InterPro

Protein Sequence (296 amino acids)

>AZOBR_RS23555 beta-lactamase (Azospirillum brasilense Sp245)
MIGRRAFLAAAGGMTVLAATRVRAEKPRNFGDKRLADAIASLEKRSGGRLGVAVLDTGTG
QRFGHRADERFPMCSTFKFLLAGAVLKRVDEGRERLDRRIPVTKADMVPYAPFAETRLDG
PPPTVAELCEATMTLSDNVAANLLLPAVGDPAGLTAFLRTLGDQKTRLDRNEPSLNSAIP
GDPRDTTTPAAMVHSMERLMLGDALTPASREQLIAWMVANRTGDKRLRAGLPKGWRVGDK
TGTGVRGTANDIGIVWPEGRAPLLITSYLTETPDAFKERDAIHAGVARAVADALKG