Protein Info for AZOBR_RS16945 in Azospirillum brasilense Sp245

Annotation: diaminopimelate decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01048: diaminopimelate decarboxylase
  • amino acids 7 to 413 (407 residues), 488.5 bits, E=6.3e-151
• PF00278: Orn_DAP_Arg_deC
  • amino acids 29 to 371 (343 residues), 97.6 bits, E=6.1e-32
• PF01168: Ala_racemase_N
  • amino acids 34 to 236 (203 residues), 35.1 bits, E=1.7e-12
• PF02784: Orn_Arg_deC_N
  • amino acids 36 to 279 (244 residues), 200.5 bits, E=4.4e-63

Best Hits

Swiss-Prot: 51% identical to DCDA_ZYMMO: Diaminopimelate decarboxylase (lysA) from Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)

KEGG orthology group: K01586, diaminopimelate decarboxylase [EC: 4.1.1.20] (inferred from 83% identity to azl:AZL_d01130)

Predicted SEED Role

"Diaminopimelate decarboxylase (EC 4.1.1.20)" in subsystem Lysine Biosynthesis DAP Pathway (EC 4.1.1.20)

MetaCyc Pathways

• aspartate superpathway (23/25 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (17/18 steps found)
• L-lysine biosynthesis I (9/9 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
• L-lysine biosynthesis III (6/7 steps found)
• L-lysine biosynthesis VI (6/7 steps found)
• L-lysine biosynthesis II (7/9 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Lysine biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 4.1.1.20

Use Curated BLAST to search for 4.1.1.20

Sequence Analysis Tools

See G8ARR1 at UniProt or InterPro

Protein Sequence (421 amino acids)

>AZOBR_RS16945 diaminopimelate decarboxylase (Azospirillum brasilense Sp245)
MSAFAYRNGVMHAESVPLSTIAAEVGTPFYCYSTAALEAHYSAYAGAFAGQDADVCYAVK
ANSNLAVIRAFARLGAGADVVSGGEMRRALAGGIPAGKIIFSGVGKTREEMRAALEAGIH
QINVESIPEVEALSEVAVSLGVTAPIAFRVNPDVDAKTHAKIATGKKENKFGVDYDHARE
VYAQAAKLPGIKPVAIAVHIGSQLTDLAPFRAAYERVAALLHVLREDGHDITRLDLGGGL
GIVYKHEAPPDIADYAAMVKSITGNLGCRISLEPGRSLVGNAGILVSRVIYLKQGLHRRF
VIIDAAMNDLIRPTLYEAYHGIVPVTEPAKGAATEPYDVVGPVCESGDTFALQRALPAMA
PDELVAILSAGAYGAVMSSTYNTRPLIPEVLVNGDQFSVIRPRVSVEELLALDRVPDWLK
D