Protein Info for AZOBR_RS10125 in Azospirillum brasilense Sp245

Annotation: sulfite reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03460: NIR_SIR_ferr
  • amino acids 63 to 122 (60 residues), 73.8 bits, 7.5e-25
  • amino acids 358 to 409 (52 residues), 37.4 bits, 1.7e-13
• PF01077: NIR_SIR
  • amino acids 130 to 283 (154 residues), 160.1 bits, E=3e-51
  • amino acids 423 to 558 (136 residues), 61.4 bits, E=7.1e-21

Best Hits

KEGG orthology group: K00381, sulfite reductase (NADPH) hemoprotein beta-component [EC: 1.8.1.2] (inferred from 82% identity to azl:AZL_009370)

Predicted SEED Role

"Sulfite reductase [NADPH] hemoprotein beta-component (EC 1.8.1.2)" in subsystem Cysteine Biosynthesis (EC 1.8.1.2)

MetaCyc Pathways

• superpathway of L-methionine biosynthesis (by sulfhydrylation) (11/12 steps found)
• superpathway of sulfate assimilation and cysteine biosynthesis (8/9 steps found)
• assimilatory sulfate reduction I (4/4 steps found)
• assimilatory sulfate reduction III (3/3 steps found)
• superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) (8/10 steps found)

KEGG Metabolic Maps

• Sulfur metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.8.1.2

Sequence Analysis Tools

See G8AMS0 at UniProt or InterPro

Protein Sequence (562 amino acids)

>AZOBR_RS10125 sulfite reductase (Azospirillum brasilense Sp245)
MNHIAPGRNAGVYSYDDIDRRFVAERVEQFRAQVERRLSGELTEDEFKPLRLMNGLYLQL
HAYMLRIAVPYGVLTARQLRKLAEIGRKYDKGYGHFTTRQNLQFNWIKLEDTPAILHELA
EVDMHALQTSGNCVRNVTTDQFVGAARDEVVDGRVYAEILRQWTTLHPEFTFLPRKFKIA
IMGSDADRAAIRVHDVGVFAKRNERGEVGFTFYVGGGLGRSPFIGKLIRDWVPEEDFVAY
LEAILRVYNQYGRRDNIYKARIKILVHELGQEKFTQEVEEEFARLRGPKYRLAPEVVDEI
RRRFGGPAFETLTDEPESFQAAKAANPDFARWVAVNVLAHKVPGYAAATISLKPAGGIPG
DATSEQMELIADLADAHSFGELRVSHAQNLVLAHVRQDALFTLWTALEANGLGTPNAGLI
GDIIACPGLDYCALANARSIPLAQAISARFADPARQQTIGELGIKISGCINACGHHHVGA
IGILGVDKKGEEFYQITVGGDPTLTTAIGDILGPAVTADETVDAIEAIVEVYLSNRHDGE
RFIDTLKRVGHGPFKERVYAAH