Protein Info for ABZR87_RS21370 in Ralstonia sp. UNC404CL21Col

Annotation: zinc-dependent alcohol dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 389 PF08240: ADH_N" amino acids 27 to 153 (127 residues), 88.4 bits, see alignment E=3.4e-29 PF00107: ADH_zinc_N" amino acids 196 to 272 (77 residues), 51.7 bits, see alignment E=8.7e-18

Best Hits

Swiss-Prot: 68% identical to FADH_METMR: S-(hydroxymethyl)glutathione dehydrogenase (fdh) from Methylobacter marinus

KEGG orthology group: None (inferred from 83% identity to ret:RHE_PB00045)

Predicted SEED Role

"Threonine dehydrogenase and related Zn-dependent dehydrogenases" in subsystem Threonine degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (389 amino acids)

>ABZR87_RS21370 zinc-dependent alcohol dehydrogenase (Ralstonia sp. UNC404CL21Col)
MKALCWHGKHDIRCDTVPDPTIQHGRDAIIKVTACAICGSDLHLFDGVMPGMESGDVVGH
ETMGEVVEVGPENTKLKVGDRVVVPFTISCGECFFCKRGFYSGCERTNPDHAKAAKLWGH
SPAGLFGYSHLLGGYAGGQAEYLRVPYADVGPIRVPEGVDDETLLFLSDIFPTGYMAAEN
CNIQPGDTIAVWGCGPVGQFAIRSAFLLGAERVIAIDTVPERLAMARAAGAQTLDFKASD
VQEALNEMTQGRGPDACIDAVGTEPETTASFDSVVDRIKVATALGTDRPHVLRQAIQCCR
NFGTVSIVGVYGGLLDKVPFGSAINRGLTFRMAQTPVQRYLPLLLERIERGEIDPSFVVT
HRGTLADGPDLYKTFRDKQDGCVKVVLKP