Protein Info for ABZR87_RS19945 in Ralstonia sp. UNC404CL21Col

Annotation: heavy metal translocating P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 763 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details transmembrane" amino acids 37 to 55 (19 residues), see Phobius details amino acids 67 to 93 (27 residues), see Phobius details amino acids 178 to 197 (20 residues), see Phobius details amino acids 231 to 250 (20 residues), see Phobius details amino acids 257 to 280 (24 residues), see Phobius details amino acids 386 to 405 (20 residues), see Phobius details amino acids 413 to 435 (23 residues), see Phobius details amino acids 562 to 583 (22 residues), see Phobius details amino acids 591 to 610 (20 residues), see Phobius details TIGR01525: heavy metal translocating P-type ATPase" amino acids 65 to 607 (543 residues), 477.7 bits, see alignment E=8.9e-147 TIGR01494: HAD ATPase, P-type, family IC" amino acids 87 to 583 (497 residues), 197.5 bits, see alignment E=4.7e-62 PF00122: E1-E2_ATPase" amino acids 117 to 214 (98 residues), 69.2 bits, see alignment E=3.5e-23 PF00702: Hydrolase" amino acids 303 to 519 (217 residues), 87.7 bits, see alignment E=2e-28 PF01814: Hemerythrin" amino acids 625 to 756 (132 residues), 54.8 bits, see alignment E=2e-18

Best Hits

KEGG orthology group: K01552, [EC: 3.6.3.-] (inferred from 91% identity to rpf:Rpic12D_4504)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.-, 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.- or 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (763 amino acids)

>ABZR87_RS19945 heavy metal translocating P-type ATPase (Ralstonia sp. UNC404CL21Col)
MHSTRLLANVALLAVSALTLAAGLWARYVGADALAQQLWLIGVVPNWVALVAAIVRSLMR
RQAGVDVLAVMSISFALLSGEVLVAAVIALMLATGRTLEDFAQARAQREMTALLGHAPKR
ANRFDDGQWRQVSLEAVQAGDRLLVRHGEVVPVDGTLSEPADLDESTLTGESLTRHRWAA
DAICSGVLNVGAAFEMIASASAEKSTFAGVVRLVGAAQSERSPSVRLADRYAFAFGGVAI
LLAGASWILTGDSARCLAVLVVATPCPLILAVPVAIVSGLSRCAKRGVLAKGGSALERLA
LADTLFFDKTGTLTSGYARLVDVECAPEYASDVVLGLAGSLAQASNHVTAEAVAKAAREQ
GATLRLPSAVVESPGAGVCGRVEGHVVAIGALPYVLGSAAVPAWVEAFVKRVSYAGASAV
FVGVDGALVGALQLIDRVRLEAPRALRLLRREGIVRQAMLTGDRPDVAESVGSMLGVTEI
YASLSPAAKLAAIRDARVNGTVIMVGDGVNDAPALAAADIGVAMGARGAAASSEAADVVL
LVDRLDRLVDAVRIAHRTRRIALQSVMIGMSLSLAAMVVAALGHLPPLAGALLQEVIDVL
AIANALRALLPNQAGAARSMISADVERLKAEHAELEPILSRIRVVADALPHMAGAAAKAA
LLSLNQSLADVLLPHERRDDTQLYPDVARLLGGDDPMAAMSAMHREIFRVTNLLDRIVAD
VSPDGPDAAVTQELQRLLYGLDAILRLHCAQEDELFHVLGREA