Protein Info for ABZR87_RS13490 in Ralstonia sp. UNC404CL21Col

Annotation: M3 family metallopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 704 PF19310: TOP_N" amino acids 40 to 160 (121 residues), 82.7 bits, see alignment E=1.9e-27 PF01432: Peptidase_M3" amino acids 235 to 696 (462 residues), 484.8 bits, see alignment E=3.8e-149

Best Hits

Swiss-Prot: 48% identical to OPDA_SALTY: Oligopeptidase A (prlC) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K01414, oligopeptidase A [EC: 3.4.24.70] (inferred from 98% identity to rpf:Rpic12D_1623)

MetaCyc: 48% identical to oligopeptidase A (Escherichia coli K-12 substr. MG1655)
Oligopeptidase A. [EC: 3.4.24.70]

Predicted SEED Role

"Oligopeptidase A (EC 3.4.24.70)" in subsystem Protein degradation (EC 3.4.24.70)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.24.70

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (704 amino acids)

>ABZR87_RS13490 M3 family metallopeptidase (Ralstonia sp. UNC404CL21Col)
MTDISPKVATPANNPLLDFSGLPRFADIRPEHITPAVDVLLERAASAVAQVKDPATPVSW
NTVVTALEDATEPLGRAWGIVSHLSAVADTPELREAHAANLPRVTEFWSGLGQDLELFEK
YKAIADSAEYATLSPARRKLLENELRGFRLGGAELPEDQKPRFAAIQEQQAQLTKAFSDH
VLDATNAYALVIDDEARLAGLPEDAKQAAQEAARRDNPEATGWKFSLHFPSYFPVLQYAN
DRALRRTLYEANVTRASELGAQYGGGKAEWDNTANMAEQLALRAEEAHMLGYRNFGEVSL
VPKMADSPEDVLRFLGELADRARPFAEKDWEELQAFAKTTLGIDKLEPWDMAYASEKLRE
ARYAFSEQEVKQYFPEPAVLDGLFNVVQTLFSVKIQPEAAEVWHPDVRFFRVESAQGELL
AQFYIDLYAREGKRGGAWMDDARGRKLLGDAGVQTPVAYLTCNFSGPVGNKPALFTHDEV
ITLFHEFGHGLHHMLTQVDELGVSGINGVEWDAVELPSQFMENFCWEWEVLSRMTRHVNS
GEPLPRKLYDSMLAAKNFQNGMATLRQIVFSAFDMHLHTDFDPKGATSVLELSRQINNRF
HVVPQAELSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEASKLGGSVLDAETG
ARYRREVLAVGGSRPAIESFTAFRGRAPSIDALLRHGGMVAETA