Protein Info for ABZR87_RS13260 in Ralstonia sp. UNC404CL21Col

Annotation: cystathionine beta-lyase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01053: Cys_Met_Meta_PP
  • amino acids 14 to 398 (385 residues), 311.3 bits, E=7.1e-97
• TIGR01324: cystathionine beta-lyase
  • amino acids 34 to 398 (365 residues), 403.4 bits, E=4e-125

Best Hits

KEGG orthology group: K01760, cystathionine beta-lyase [EC: 4.4.1.8] (inferred from 98% identity to rpf:Rpic12D_1579)

Predicted SEED Role

"Cystathionine beta-lyase (EC 4.4.1.8)" in subsystem Methionine Biosynthesis (EC 4.4.1.8)

MetaCyc Pathways

• hydrogen sulfide biosynthesis II (mammalian) (1/6 steps found)

KEGG Metabolic Maps

• Biosynthesis of plant hormones
• Cysteine metabolism
• Methionine metabolism
• Nitrogen metabolism
• Selenoamino acid metabolism
• Sulfur metabolism

Isozymes

Compare fitness of predicted isozymes for: 4.4.1.8

Use Curated BLAST to search for 4.4.1.8

Protein Sequence (403 amino acids)

>ABZR87_RS13260 cystathionine beta-lyase (Ralstonia sp. UNC404CL21Col)
MTDDTKLPPMFPATQVVHPDLHIPPGFTAFSHATHRASTVVFKNLADMRAFGSGSVVHWR
YGLHATPTSDTLCQALAQIEGGSHTLLLPSGLAAISLVYFSLIKSGDDVLIPDNAYGPNR
DHGEWMARQFGITVRYYDPMIGAGIADLMRHNTKLVWLEAPGSVTMEVPDCTAIAEVARK
AGAITAIDNTWSGGVYYQPFEHGIDISVQALTKYQSGGSDVLMGAAITNDEALHHKLLAT
RMRMGWGVSADDCYFVLRGLPSLPTRLAAHDAHAREVAEWLADRPEVVRVLHPALPDCPG
HENWKRDFTGASGLFSIVLHERYSQAQIDAFIEGLRYFAIGFSWGGAHSLALPYNIPSMR
TATAWPPADWENAGGFVRLYIGLEDPRDLIADLKQAMETHLRA