Protein Info for ABZR87_RS08595 in Ralstonia sp. UNC404CL21Col

Annotation: Hpt domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 200 400 600 800 1000 1200 1400 1600 1800 2022 transmembrane" amino acids 262 to 280 (19 residues), see Phobius details PF01627: Hpt" amino acids 759 to 858 (100 residues), 47.9 bits, see alignment 2.6e-16 amino acids 1051 to 1141 (91 residues), 40.8 bits, see alignment 4.3e-14 amino acids 1242 to 1338 (97 residues), 49.1 bits, see alignment 1.1e-16 PF02518: HATPase_c" amino acids 1587 to 1722 (136 residues), 58.7 bits, see alignment 1.5e-19 PF01584: CheW" amino acids 1727 to 1856 (130 residues), 66.5 bits, see alignment 4.1e-22 PF00072: Response_reg" amino acids 1897 to 2008 (112 residues), 88 bits, see alignment 9.5e-29

Best Hits

KEGG orthology group: K02487, type IV pili sensor histidine kinase and response regulator K06596, chemosensory pili system protein ChpA (sensor histidine kinase/response regulator) (inferred from 95% identity to rpi:Rpic_0616)

Predicted SEED Role

"Signal transduction histidine kinase CheA (EC 2.7.3.-)" in subsystem Bacterial Chemotaxis or Flagellar motility or Two-component regulatory systems in Campylobacter (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.3.-

Use Curated BLAST to search for 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (2022 amino acids)

>ABZR87_RS08595 Hpt domain-containing protein (Ralstonia sp. UNC404CL21Col)
MRHQSSAQPESASVEAVGAPAGRQKSVPKPAVPARDLSALAWVAPNMRAALDDAVREFGE
YAADVIADPEVIGARDTTSLRLAGQYLHQAAGALLIVGLRGVDVYCQAAKRLLEAVDTGS
VAADAQTLDVFSRAVQALQEYVSDLMAGMAEEPLRLFQPYQAVLARLGEERIHPADLWAD
ELRHLPALLLPSRDLPGLARLRRKFELALLTALRAPASNADGAVVDPAAAAAAYAPLEDL
LHGIRALEREPRRAGDDLQRDLWLVLALTFGALRAGLVPADMTAKRLAARVNLLLRQYSH
NNVHLPQGLLTDALYLLAGMAYSNAPAVPVGDDTLGPDIVACVQAFAIPPTHAPAGALHT
RQYYALLPTDASDTLQRVGRSLETLSQQPAPAADELDAALQTLALHADALGQPALSDLSN
RLTEAAGQDVAPTLQFLSRMLARPWALHGESGDLRSAWFAARCSELAEHARATQDGHAVP
APAWLTLLAEQAAERRSRADQVRALQTLLASAETHLDAFEREGAESGGLQEAARLFGEMQ
SAFAALDAYEAVHATEAAQSTIDALQAAGEGATADRERYLAALAANVSGLQALLDALSAS
TELTGGQVDEIVIEGQLTPTERETAWREFAFDTEAGMLARREPQSEAQAGADIANADAAS
PLQSLLDRLLAKQPVDPTDPLAAELRTALQEARDAAAIDDDPARRRRLEEALAQFDAWQV
GSAGALERMQAALAAPAAVPAAAAPAPAAARDTQSIDAELLDIFLSEAEEVLAGVRADLQ
GLQAAADMGTGGLAAGSDLDLLTQLRRAFHTLKGSGRMVGLTRYGEAAWAIEQVMNVWLA
ESRVPTHDLAALLTRAESELSTWAAAIAQSPQADHAIEPLVAAAERVRHGGPFVWLEAVP
ASEASEPAEVAPAAEYAEPQPVEAPVADTASHDAVAEPSLELAAPDAPVAETETEAEDAV
ALTWDDEPALPEVEAPMPEATAPLVEHEAAEPVAEHVEETIQEAAAEPVAADADADAKVI
PFPFAQTGEPEEAPHDDGVKEIGPVRISVALYNVYLQEADDLIRRLGVDFSEWRHEGRTP
PSELALRAAHTLQGSSAVVELEPVRQLAAALEQVLLNLNSRPVAMHPGDFRLLDQAVERM
RGMLHQFAASLWPETDEPLRRSLDELCERLLVRPRLPLEPAPAAFTEAEQAENETAGLAG
EPDFEPAQVTSTFVPAHESPVAEPAVGELVRQAPTDALDPALLEIFLEEAHVALPELGQH
LRAWEAAPQDRNAAGLLLRNLHTVKGSARMAGAMTLGQAAHEMESAIEGGLRQNRVDDAL
FRKLYVWFDRIQAHVDALGAGNLLPLDAGLADAADVQQTADAQASSSASMLPAVAVSTSV
DLTGTRSPEAEALEVAERQRAMVRVQARALDSLINDAGEVGAARARLESEVDALKTYLSE
LNDNVARLRSQVREIEIQAETQMESRIADAAAHSEAFDPLEFDRFTRLQELTRMMAESVN
DVATVQQNLFRGFDQASLDLETQARLTRGLQRSLMRARMVQFDTVADRLYRVARQAAAET
GKEVRLFIKGGTVELDRSVLDRMGGPLEHMIRNAVAHGIESADERRAKGKAPAGELTLEV
QQEGNEVVLHFVDDGAGLNLDRIRARALERQLLAADEEASDARLTEMIFTPGFSTADQVS
ELAGRGVGMDVVRAETVALGGRISLQTTPEVGTRFTIHLPLTTAITQVLLVRVSERVYAI
PSGMIDHVQQLRPQALAEAYNAAALQLPTGPVPFHYFGALLEEATSVTGGRKYSPAVVVR
NGADRAAVHVDEVIGNREVVVKHIGPHLARLEGIAGATTLGDGEIVLIYNPVVLTQRFER
EAVARSLSDPEATGAVAELQRDGSTDAVPGLATQPIVMVVDDSLTVRKVTQRLLTRSGYQ
AVLARDGVDALRQLQEITPDAMLVDIEMPHMDGFDLTRNVRADERIGATPIIMITSRTAD
KHRRYAAEIGVNVYLGKPYNEEELLQHLRNLIGERAPAANAG