Protein Info for ABZR87_RS05225 in Ralstonia sp. UNC404CL21Col

Annotation: cache domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 479 signal peptide" amino acids 1 to 35 (35 residues), see Phobius details transmembrane" amino acids 207 to 230 (24 residues), see Phobius details PF17200: sCache_2" amino acids 47 to 195 (149 residues), 120.1 bits, see alignment E=2.1e-38 PF08269: dCache_2" amino acids 77 to 189 (113 residues), 110.2 bits, see alignment E=3e-35 PF17201: Cache_3-Cache_2" amino acids 83 to 196 (114 residues), 47.7 bits, see alignment E=3.5e-16 PF07730: HisKA_3" amino acids 254 to 326 (73 residues), 53.5 bits, see alignment E=7e-18 PF02518: HATPase_c" amino acids 373 to 464 (92 residues), 53.1 bits, see alignment E=1e-17

Best Hits

KEGG orthology group: K02480, two-component system, NarL family, sensor kinase [EC: 2.7.13.3] (inferred from 97% identity to rpf:Rpic12D_3405)

Predicted SEED Role

"Sensor histidine kinase"

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (479 amino acids)

>ABZR87_RS05225 cache domain-containing protein (Ralstonia sp. UNC404CL21Col)
MKLRQKILLLAVAPLTIAMLAIMLTVRHQSIALARHERQLVESAYLQAKETELRSYVKLA
QSAIAPLLAAGHGADPARDEATRDEAMRTLARLDFGTDGYFFLYDLRGRNLMHPRQPELV
GRDLWDLTDSGGQPTIQKLVAAAQAGGGFVRYMWDKPSTHQSVPKLGYVEPIPQWGWMVG
TGLYLDDIEQTLREIDRRAQTNIDQTLAWVVGIAAVSILLVAGSGLALNVSDHRQADAKL
RQLAQQVVKSQEDERARVSRELHDGISQVLVSTKLLLETAHGHLEAGPASPASIERADSM
LRRALDRLNGALGEVRRVSHNLRPALLDDLGLAAALELLVRETREAHEDSQPGFAIALEL
VGPPVQLPDACNTALFRIAQEAVSNIERHATQATRIGVLLENDIDAVRLSVRDNGPGFDV
ESVQVDPQHGIGLRNMRERMAALGGTCTIASGPHGTEVTAVLPHGVIARLASAPSSPLV