Protein Info for ABZR87_RS04855 in Ralstonia sp. UNC404CL21Col

Annotation: adenosylhomocysteinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF05221: AdoHcyase
  • amino acids 10 to 473 (464 residues), 491.6 bits, E=1.2e-151
• TIGR00936: adenosylhomocysteinase
  • amino acids 11 to 466 (456 residues), 609.1 bits, E=1.9e-187
• PF00670: AdoHcyase_NAD
  • amino acids 231 to 390 (160 residues), 269.7 bits, E=1.5e-84
• PF02826: 2-Hacid_dh_C
  • amino acids 250 to 340 (91 residues), 32.1 bits, E=1.1e-11

Best Hits

Swiss-Prot: 98% identical to SAHH_RALPJ: Adenosylhomocysteinase (ahcY) from Ralstonia pickettii (strain 12J)

KEGG orthology group: K01251, adenosylhomocysteinase [EC: 3.3.1.1] (inferred from 98% identity to rso:RSc0093)

Predicted SEED Role

"Adenosylhomocysteinase (EC 3.3.1.1)" in subsystem Methionine Biosynthesis or Methionine Degradation (EC 3.3.1.1)

MetaCyc Pathways

• S-adenosyl-L-methionine salvage II (3/3 steps found)
• L-methionine degradation I (to L-homocysteine) (2/3 steps found)
• superpathway of L-cysteine biosynthesis (mammalian) (2/5 steps found)
• superpathway of L-methionine salvage and degradation (7/16 steps found)

KEGG Metabolic Maps

• Methionine metabolism
• Selenoamino acid metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.3.1.1

Protein Sequence (474 amino acids)

>ABZR87_RS04855 adenosylhomocysteinase (Ralstonia sp. UNC404CL21Col)
MNAVTELKHDYLVADIKLADWGRKEIAIAETEMPGLMAIREEFAASQPLKGARIAGSLHM
TIQTAVLIETLKALGADVRWASCNIFSTQDHAAAAIAASGTPVFAFKGESLKEYWDFTHR
IFEWADGGTPNMILDDGGDATLLLHLGAKAEKDASVIAKPTSEEETFLFAAIKEKLAKDA
TFYSRNLDAIKGVTEETTTGVHRLYQMAQRGELRFPAINVNDSVTKSKFDNLYGCRESLV
DGIKRATDVMIAGKVAVVAGYGDVGKGSAQALRALSAQVWVTEIDPICALQAAMEGYRVV
TMDYAAEHGDIFVTCTGNYHVITHDHMAKMKDQAIVCNIGHFDNEIDIASVEKYQWEEIK
PQVDHVIFPDGKKIIILAKGRLVNLGCATGHPSYVMSSSFANQTIAQIELWTEAVKGSNK
YPVGVYTLPKHLDEKVARLQLKKLNAQLTELTDQQAAYIGVSKEGPYKADHYRY