Protein Info for ABZR87_RS04680 in Ralstonia sp. UNC404CL21Col

Annotation: nickel/cobalt efflux protein RcnA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 375 transmembrane" amino acids 12 to 30 (19 residues), see Phobius details amino acids 52 to 77 (26 residues), see Phobius details amino acids 89 to 107 (19 residues), see Phobius details amino acids 271 to 295 (25 residues), see Phobius details amino acids 305 to 329 (25 residues), see Phobius details amino acids 349 to 368 (20 residues), see Phobius details PF03824: NicO" amino acids 14 to 125 (112 residues), 66.1 bits, see alignment E=3.4e-22 amino acids 233 to 363 (131 residues), 72.6 bits, see alignment E=3.6e-24 PF13386: DsbD_2" amino acids 264 to 339 (76 residues), 32.5 bits, see alignment E=8.5e-12

Best Hits

KEGG orthology group: K08970, nickel/cobalt exporter (inferred from 78% identity to rso:RS03927)

Predicted SEED Role

"Inner membrane protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (375 amino acids)

>ABZR87_RS04680 nickel/cobalt efflux protein RcnA (Ralstonia sp. UNC404CL21Col)
MTAFTTLLQQGNAWLFVPSAILLGALHGLEPGHSKTMMAAFIVAIRGTLTQAVLLGLSAT
VSHTAVVWAVAMAGLYFGRNWNAETTEPYFQMVSAVLIVAVAAWMMWRTWRSTHAAHDHD
HHHHDHGHDDVQRIDTGHGVVQLAIFEDGVPPRFRLTREGTRGTAWSAEQVQVVTERPDG
SRQTFRFVQRDGFLESEQVIPEPHAFVARLSLGHEHHRHDYDVTFSEHDHDHDRDHSHGG
LDVSSAEYQDAHERAHANDIRRRFTNREVTTGQIIVFGLTGGLIPCPASITVLLLCLQLK
KITLGAALVLCFSIGLALTLVASGALAALSVKHVSRRWGGFGEFARQAPYLSGVLIALVG
LYVGWQGVHGVMQLP