Protein Info for ABZR87_RS03860 in Ralstonia sp. UNC404CL21Col

Annotation: C4-dicarboxylate transporter DctA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 446 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details transmembrane" amino acids 46 to 64 (19 residues), see Phobius details amino acids 76 to 98 (23 residues), see Phobius details amino acids 152 to 170 (19 residues), see Phobius details amino acids 190 to 211 (22 residues), see Phobius details amino acids 222 to 247 (26 residues), see Phobius details amino acids 260 to 278 (19 residues), see Phobius details amino acids 291 to 320 (30 residues), see Phobius details amino acids 324 to 341 (18 residues), see Phobius details amino acids 352 to 375 (24 residues), see Phobius details amino acids 380 to 403 (24 residues), see Phobius details PF00375: SDF" amino acids 8 to 403 (396 residues), 353.4 bits, see alignment E=8.3e-110

Best Hits

Swiss-Prot: 91% identical to DCTA2_RALSO: C4-dicarboxylate transport protein 2 (dctA2) from Ralstonia solanacearum (strain GMI1000)

KEGG orthology group: K11103, aerobic C4-dicarboxylate transport protein (inferred from 99% identity to rpi:Rpic_3473)

MetaCyc: 51% identical to C4 dicarboxylate/orotate:H+ symporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-121; TRANS-RXN-121A; TRANS-RXN-121C; TRANS-RXN-122A; TRANS-RXN0-451; TRANS-RXN0-517; TRANS-RXN0-553

Predicted SEED Role

"sodium:dicarboxylate symporter"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (446 amino acids)

>ABZR87_RS03860 C4-dicarboxylate transporter DctA (Ralstonia sp. UNC404CL21Col)
MQRFTRPLFGQVLIALAVGIALGIWAPEFAQKLQPLGDGFLKLIKMLIAPIVFSVVVVGI
CGAGELKKVGRVGGKAVIYFEIVTTIALALGIALAYVFGPGHGMNVDPKSLDPAAMASYM
TTAKQVESTGVAAFFLKLIPDTFVSGFVKGDILQVLLVSILFGCSLSLLGERTKPLVNLI
DQLSHVLFRMMAVIIRLAPLGVLGAVAFTVGKYGAGSLKQLGFLVLLFYAAVALFVFVVL
GTILRVAGFNIFKLIRFLRAELLVVLGTASSDAVLPSIMNKLEKMGIKRSVVGLVIPTGY
SFNLDAFSIYLTLAAVFIAQATNTPLALQDLLLILGVALVTSKGAHGIPGSAIVILAATL
SVIPAIPAIGLVLVLSVDWFIGIARALGNLIGNCVATVVIAAWEKDIDRVRANAVLDGKI
DITEEGEAIPHGLGVAAPAAHTLPHA