Protein Info for ABZR87_RS02695 in Ralstonia sp. UNC404CL21Col

Annotation: protein-disulfide reductase DsbD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 610 signal peptide" amino acids 1 to 32 (32 residues), see Phobius details transmembrane" amino acids 184 to 212 (29 residues), see Phobius details amino acids 224 to 248 (25 residues), see Phobius details amino acids 259 to 281 (23 residues), see Phobius details amino acids 304 to 333 (30 residues), see Phobius details amino acids 340 to 362 (23 residues), see Phobius details amino acids 374 to 394 (21 residues), see Phobius details amino acids 400 to 420 (21 residues), see Phobius details amino acids 437 to 456 (20 residues), see Phobius details PF11412: DsbD_N" amino acids 33 to 148 (116 residues), 113.6 bits, see alignment E=1.7e-36 PF13386: DsbD_2" amino acids 189 to 377 (189 residues), 45.8 bits, see alignment E=2.2e-15 PF02683: DsbD" amino acids 190 to 369 (180 residues), 78.5 bits, see alignment E=2e-25 PF13899: Thioredoxin_7" amino acids 493 to 573 (81 residues), 49.4 bits, see alignment E=1.3e-16 PF13098: Thioredoxin_2" amino acids 503 to 594 (92 residues), 39.1 bits, see alignment E=2.4e-13

Best Hits

Swiss-Prot: 79% identical to DSBD_RALSO: Thiol:disulfide interchange protein DsbD (dsbD) from Ralstonia solanacearum (strain GMI1000)

KEGG orthology group: K04084, thiol:disulfide interchange protein DsbD [EC: 1.8.1.8] (inferred from 92% identity to rpi:Rpic_3268)

Predicted SEED Role

"Cytochrome c-type biogenesis protein DsbD, protein-disulfide reductase (EC 1.8.1.8)" in subsystem Biogenesis of c-type cytochromes or Periplasmic disulfide interchange (EC 1.8.1.8)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.8.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (610 amino acids)

>ABZR87_RS02695 protein-disulfide reductase DsbD (Ralstonia sp. UNC404CL21Col)
MTFSSFRSVRRMVQCLLLLVAMATVHVSAHAADDFLPPEQAFRFSAAQVDGQTVEIKFAI
ADGYYMYRERFAVAADPATTTLSLSDMPAGKVKFDETFNKDVETYRHEVAFHVKAQNATA
PFTLIVTSQGCADQGLCYPPMKSRFHVEPAAVSPGASSVGGGETSSGDALGRIASTLGSG
NLGAIAALFFGLGLLLTFTPCVLPMLPILSAIVVGEHATRSRAAFVSIAYVLGMAVVYTA
VGVAAGLAGQGLQAALQNAWVLGAFAVLMVVLSLSMFGLYELQLPAAWRDHLTKASSRHG
GGEIVGAVVMGALSALIVSPCVTPALAGALAYIAQTGNAAIGGMALFAMSIGMGVPLVLV
GVGAGNLLPRAGHWLIVTKAVFGFILLAVALWIVQPVLPAWAVMVAWGGLLIGAAVFLRT
FDSLPDGAGNVQRLGKVAGVVLALAGAAQLVGVAAGGRDPLQPLSGLVRASAGTSAQADT
QGVTFKRVKSITELDAEVRNASASGRAVMLDFYADWCVSCKEMERLTFTDARVRKALADV
VLLQADVTANNADDQALLKRFGLFGPPGTIFFDTQGRELKARVVGFERADTFLESLRRAI
GTTQAVKPTA