Protein Info for ABZR87_RS00150 in Ralstonia sp. UNC404CL21Col

Annotation: leucyl aminopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 502 PF02789: Peptidase_M17_N" amino acids 24 to 145 (122 residues), 103.6 bits, see alignment E=7.6e-34 PF00883: Peptidase_M17" amino acids 194 to 494 (301 residues), 435.6 bits, see alignment E=1.1e-134

Best Hits

Swiss-Prot: 99% identical to AMPA_RALPJ: Probable cytosol aminopeptidase (pepA) from Ralstonia pickettii (strain 12J)

KEGG orthology group: K01255, leucyl aminopeptidase [EC: 3.4.11.1] (inferred from 99% identity to rpf:Rpic12D_2219)

Predicted SEED Role

"Cytosol aminopeptidase PepA (EC 3.4.11.1)" (EC 3.4.11.1)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.11.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (502 amino acids)

>ABZR87_RS00150 leucyl aminopeptidase (Ralstonia sp. UNC404CL21Col)
MEFSTKALDWAKAGALAAKSDCLVIGLFESQTLAGAAKALDVATKGLVARLVKLGDFEGK
RGTSLLLHEVAGVGAARVLLVGLGKEADFTDRAYAEAVRTALRALASTKAASVTWTLTEH
TARDKDTAWAVLTAVTLIREASYRFIERHPELKSKRDKSSTGLRKLVLSVPAADAKAASV
AATRGTAIANGMDLTRDLGNLPSNICTPTYLANTARQIAKDFKLKVEVLGRKQIEALKMG
AFLAVTKGSEEPPQFIVLRYEGGPAKQAPVVLVGKGITFDTGGISLKPGEGMDEMKYDMC
GAASVLGTLRAVAEMGLKQNVIAVVPTCENMPSGIATKPGDVVTSMSGQTIEILNTDAEG
RLILCDALTYVERFKPAVVIDVATLTGACIIALGHINTGMYARSDALADALVAAGKQSLD
TAWRMPLDEEYQEQLKSNFADMGNIGGRPAGSVTAACFLARFTEKYDWAHLDIAGTAWKS
GAAKGATGRPVPLLTRFLMDRG