Protein Info for ABZR86_RS10905 in Dyella japonica UNC79MFTsu3.2

Annotation: threonine-phosphate decarboxylase CobD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 336 TIGR01140: threonine-phosphate decarboxylase" amino acids 4 to 323 (320 residues), 354.6 bits, see alignment E=2.6e-110 PF00155: Aminotran_1_2" amino acids 63 to 308 (246 residues), 102.2 bits, see alignment E=1.9e-33

Best Hits

KEGG orthology group: K02225, cobalamin biosynthetic protein CobC (inferred from 67% identity to xca:xccb100_1133)

Predicted SEED Role

"L-threonine 3-O-phosphate decarboxylase (EC 4.1.1.81)" in subsystem Cobalamin synthesis or Coenzyme B12 biosynthesis (EC 4.1.1.81)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.81

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1I2FB77 at UniProt or InterPro

Protein Sequence (336 amino acids)

>ABZR86_RS10905 threonine-phosphate decarboxylase CobD (Dyella japonica UNC79MFTsu3.2)
MLEHGGRLLRAAHEYGMPPEAWLDLSTGVSPFAWPVPPLPAAAWHRLPEDDDGLIEVARA
YYRHASLLPVAGSQAAIQALPALRHRARVGVLDPGYAEHPQAWQRAGHKVERAAADALFS
RAARYDVIVLIHPNNPGGERFELDALLALHASLARRGGWLVVDEAFIDATPGDSLCEAHA
LPGLIVLRSVGKFFGLAGARAGFVCAEPALLVALRERLGPWTLSGPTRQVLKLALADTAW
QAAQRERLHATSARLSALLARHGLAPAAGCAFFQWRRDERATAMQRALARQGVLVRRFEQ
PHSIRFGLPGDEAAFARLDAALASWRTVETKRETTP