Protein Info for ABZR86_RS10020 in Dyella japonica UNC79MFTsu3.2

Annotation: CDP-glucose 4,6-dehydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 356 TIGR02622: CDP-glucose 4,6-dehydratase" amino acids 6 to 348 (343 residues), 458.4 bits, see alignment E=8.1e-142 PF04321: RmlD_sub_bind" amino acids 11 to 166 (156 residues), 38 bits, see alignment E=3.1e-13 PF01370: Epimerase" amino acids 11 to 245 (235 residues), 109 bits, see alignment E=8.1e-35 PF16363: GDP_Man_Dehyd" amino acids 12 to 320 (309 residues), 110.3 bits, see alignment E=4.2e-35 PF01073: 3Beta_HSD" amino acids 14 to 166 (153 residues), 24.8 bits, see alignment E=3.2e-09 PF07993: NAD_binding_4" amino acids 57 to 192 (136 residues), 28.4 bits, see alignment E=2.8e-10 PF02719: Polysacc_synt_2" amino acids 66 to 192 (127 residues), 35.7 bits, see alignment E=1.7e-12

Best Hits

KEGG orthology group: K01709, CDP-glucose 4,6-dehydratase [EC: 4.2.1.45] (inferred from 53% identity to bpm:BURPS1710b_A1962)

MetaCyc: 49% identical to CDP-D-glucose-4,6-dehydratase monomer (Yersinia pseudotuberculosis)
CDP-glucose 4,6-dehydratase. [EC: 4.2.1.45]

Predicted SEED Role

"Similar to CDP-glucose 4,6-dehydratase (EC 4.2.1.45)" (EC 4.2.1.45)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.45

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1I2IJE8 at UniProt or InterPro

Protein Sequence (356 amino acids)

>ABZR86_RS10020 CDP-glucose 4,6-dehydratase (Dyella japonica UNC79MFTsu3.2)
MSAHAWSGRSVLLTGHTGFKGSWLSLMLRGLGARVHGYALDPIGEPSLFERGRIAETLAT
DCRANLLDLPTLTAALERAAPEVVLHLAAQPLVKVGYADPVGTFATNVMGTAHLLEACRR
VGSVKAIIVVTTDKVYRNEEDGQAYAESEPLGGHDPYSASKAAAEIVSASYRSSYLHGVV
PLATARAGNVLGGGDWAADRLVPDCIRAFEAGETVHLRRPGAIRPWQHVLEPLSGYLTLA
EHLLASDGEKYAQAWNFGPEPSSVCTVEEVAIQVAELWGAGAKVTASHEEGFHEAGVLRL
DSSKAASLLQWHPRWTLSQALGATVEWHKSFRAGEDMQRVCERQIEAYAQGRVAHG