Protein Info for ABZR86_RS08855 in Dyella japonica UNC79MFTsu3.2

Annotation: replicative DNA helicase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 464 PF00772: DnaB" amino acids 20 to 121 (102 residues), 117.1 bits, see alignment E=5.1e-38 TIGR00665: replicative DNA helicase" amino acids 20 to 455 (436 residues), 599.3 bits, see alignment E=4.3e-184 TIGR03600: phage replicative helicase, DnaB family" amino acids 23 to 444 (422 residues), 499 bits, see alignment E=1.2e-153 PF03796: DnaB_C" amino acids 198 to 453 (256 residues), 382.2 bits, see alignment E=1.6e-118 PF13481: AAA_25" amino acids 203 to 376 (174 residues), 34.5 bits, see alignment E=2.4e-12

Best Hits

Swiss-Prot: 52% identical to DNAB_HAEIN: Replicative DNA helicase (dnaB) from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

KEGG orthology group: K02314, replicative DNA helicase [EC: 3.6.4.12] (inferred from 68% identity to psu:Psesu_1675)

Predicted SEED Role

"Replicative DNA helicase (EC 3.6.1.-)" in subsystem DNA-replication (EC 3.6.1.-)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.6.1.-, 3.6.4.12

Use Curated BLAST to search for 3.6.1.- or 3.6.4.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1I2DFD3 at UniProt or InterPro

Protein Sequence (464 amino acids)

>ABZR86_RS08855 replicative DNA helicase (Dyella japonica UNC79MFTsu3.2)
MSFAPDRKHGNSAIEALRVPPHSIEAEQAVLGGLMLSPDSLDKVADRLGERDFYRKDHRL
IWRAITELANKGMPCDAVTLGDWFEANGLAELVGGATYLVELANATPSAANIGAYADIVR
EKSILRQLIDAGTETTEDGYRPEGRSVQEVLESAEQRVFKIAESGARGKKDTVSMREAVK
DAFRILSERYENRGQLTGISTGFTDLDELTSGLQPSDLIIVAARPSMGKTAFSVNIAEAA
ALGAKKAVAIFSMEMSASQLAFRMISSIGRIHAQHLRNGDLAEEDWPRVTNAIALLSEAK
IFIDDTPGLSPVELRSRSRRLHREHGGLGLIVIDYLQLMQVPGNKENRATEISEISRSLK
GLAKELNCPVIALSQLNRSLEQRADKRPMMSDLRESGAIEQDADVIMFIYRDDYYNKESP
DKGLAEIIIGKQRNGPTDTVKLTFLGHYTKFMNYAPDSFVGAFE