Protein Info for ABIE53_005460 in Paraburkholderia graminis OAS925

Annotation: DHA2 family multidrug resistance protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 538 transmembrane" amino acids 32 to 52 (21 residues), see Phobius details amino acids 72 to 92 (21 residues), see Phobius details amino acids 99 to 119 (21 residues), see Phobius details amino acids 125 to 150 (26 residues), see Phobius details amino acids 158 to 180 (23 residues), see Phobius details amino acids 187 to 208 (22 residues), see Phobius details amino acids 222 to 240 (19 residues), see Phobius details amino acids 253 to 274 (22 residues), see Phobius details amino acids 292 to 314 (23 residues), see Phobius details amino acids 326 to 347 (22 residues), see Phobius details amino acids 355 to 372 (18 residues), see Phobius details amino acids 392 to 411 (20 residues), see Phobius details amino acids 423 to 440 (18 residues), see Phobius details amino acids 500 to 524 (25 residues), see Phobius details TIGR00711: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family" amino acids 33 to 522 (490 residues), 396.1 bits, see alignment E=1.1e-122 PF07690: MFS_1" amino acids 38 to 432 (395 residues), 142.2 bits, see alignment E=9.8e-46

Best Hits

KEGG orthology group: None (inferred from 94% identity to bxe:Bxe_B0737)

Predicted SEED Role

"Inner membrane component of tripartite multidrug resistance system" in subsystem Multidrug Resistance, Tripartite Systems Found in Gram Negative Bacteria

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (538 amino acids)

>ABIE53_005460 DHA2 family multidrug resistance protein (Paraburkholderia graminis OAS925)
MTQALANSAGPATPATPAAPANPAELPTRIKVLAFTLMCVGFFMATLDIQIVASSLKDIG
GGLSASQDELSWVQTSYLIAEIVVIPMSGWLTRVFSTRWVFAFSALGFTIASMLCGLAWD
INSMILFRGLQGALGAAMIPTVFTTAFVLFPGKQRLIASTTISALATLAPTIGPVIGGWI
TSQWSWHWLFYLNLVPGVAVALLVPKYVHFDNADLSLLKKGDYFGILLMSGFLACLEYVL
EEGPRKNWFGDDVIVTCTWITAICGFLFIVHAFTAKEPIVDLRALAVRNFGIGSLLSFIT
GIGIFCAVFLTPVFLSRVRGFDSLQIGVALLSVGCFQLAAMVVYSVVARFVDMRILLVIG
LVLFGLGCYLYVPLTSQWGWRELLIPQALRGIGQQFCIPPIVTMALGSLPMSRLRSASGL
FNLMRNLGGAIGIAVSSTMLNDRLNLHYERLDEHLNAGRPVVQSVLQQQTAHFAAVGGNA
LNAANAGLAQLHALLMREALVLTFSDTFFALSLCFVVGLLSVLLSRPFGNAAPPPDAH