Protein Info for ABIE53_003889 in Paraburkholderia graminis OAS925

Annotation: methylthioribose-1-phosphate isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00512: S-methyl-5-thioribose-1-phosphate isomerase
  • amino acids 13 to 341 (329 residues), 433.4 bits, E=5e-134
• TIGR00524: eIF-2B alpha/beta/delta-related uncharacterized proteins
  • amino acids 41 to 341 (301 residues), 356.5 bits, E=1.1e-110
• PF01008: IF-2B
  • amino acids 53 to 340 (288 residues), 293 bits, E=1.1e-91

Best Hits

Swiss-Prot: 53% identical to MTNA_MOOTA: Methylthioribose-1-phosphate isomerase (mtnA) from Moorella thermoacetica (strain ATCC 39073 / JCM 9320)

KEGG orthology group: K08963, methylthioribose-1-phosphate isomerase [EC: 5.3.1.23] (inferred from 62% identity to dap:Dacet_2111)

MetaCyc: 44% identical to 5-fluoro-5-deoxy-ribose 1-phosphate isomerase (Streptantibioticus cattleyicolor)
5.3.1.-

Predicted SEED Role

"Methylthioribose-1-phosphate isomerase (EC 5.3.1.23)" in subsystem Methionine Salvage (EC 5.3.1.23)

MetaCyc Pathways

• 5'-deoxyadenosine degradation II (4/4 steps found)
• 5'-deoxyadenosine degradation I (2/3 steps found)
• S-methyl-5-thio-α-D-ribose 1-phosphate degradation II (2/5 steps found)
• S-methyl-5-thio-α-D-ribose 1-phosphate degradation III (2/5 steps found)
• fluoroacetate and fluorothreonine biosynthesis (1/6 steps found)
• L-methionine salvage cycle I (bacteria and plants) (5/12 steps found)
• L-methionine salvage cycle II (plants) (4/11 steps found)
• S-methyl-5-thio-α-D-ribose 1-phosphate degradation I (1/7 steps found)
• L-methionine salvage cycle III (3/11 steps found)

KEGG Metabolic Maps

• Methionine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.3.1.23

Protein Sequence (359 amino acids)

>ABIE53_003889 methylthioribose-1-phosphate isomerase (Paraburkholderia graminis OAS925)
MVAQSLFPALAPTIEWRDGDLLLLDQTRLPHEIVVEHVADAAAVWRAIHELRVRGAPAIG
VAAAYGLCVAVQDARALPLAQFRAELERRARWLDTARPTAVNLSWSLRRMLQRALTCGAS
DTAALYAALVDEAQQIHAEDQALCEGIGRHGMPLIGQGSGVLTHCNAGALATTGLGTATA
PIYAAHREGVTFKVFADETRPLLQGARLTAFELQQAGVDVTLIMDSAAASIMSQGLVDLV
IVGTDRVAANGDFANKIGTLGVAIAAKHYGIPFYVACPSSTLDFRTPSGAQIEIEERCDE
EVTHIAGQRTAAPGIKVRNPAFDVTPQELVTGFITERGIVRAPFERSLGSLFPAAGNAA