Protein Info for ABIE53_003757 in Paraburkholderia graminis OAS925

Annotation: thiol:disulfide interchange protein DsbD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 619 signal peptide" amino acids 1 to 35 (35 residues), see Phobius details transmembrane" amino acids 190 to 215 (26 residues), see Phobius details amino acids 235 to 259 (25 residues), see Phobius details amino acids 271 to 295 (25 residues), see Phobius details amino acids 315 to 344 (30 residues), see Phobius details amino acids 352 to 379 (28 residues), see Phobius details amino acids 391 to 408 (18 residues), see Phobius details amino acids 414 to 436 (23 residues), see Phobius details amino acids 448 to 467 (20 residues), see Phobius details PF11412: DsbD_N" amino acids 36 to 149 (114 residues), 114.2 bits, see alignment E=1.1e-36 PF13386: DsbD_2" amino acids 198 to 399 (202 residues), 33.1 bits, see alignment E=1.6e-11 PF02683: DsbD" amino acids 199 to 401 (203 residues), 60.8 bits, see alignment E=5.4e-20 PF13098: Thioredoxin_2" amino acids 518 to 609 (92 residues), 49 bits, see alignment E=2e-16 PF13899: Thioredoxin_7" amino acids 518 to 589 (72 residues), 42 bits, see alignment E=2.6e-14

Best Hits

KEGG orthology group: K04084, thiol:disulfide interchange protein DsbD [EC: 1.8.1.8] (inferred from 89% identity to bug:BC1001_3252)

Predicted SEED Role

"Cytochrome c-type biogenesis protein DsbD, protein-disulfide reductase (EC 1.8.1.8)" in subsystem Biogenesis of c-type cytochromes or Periplasmic disulfide interchange (EC 1.8.1.8)

Isozymes

Compare fitness of predicted isozymes for: 1.8.1.8

Use Curated BLAST to search for 1.8.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (619 amino acids)

>ABIE53_003757 thiol:disulfide interchange protein DsbD (Paraburkholderia graminis OAS925)
MFNGLNRRARHALRTALLVFACLILAQFGSLARASDDFLDPAVAFKFSATEKPGEVDVTY
KIADGYYMYRERFAFAARNGNATIGEPQLPAGHIKFDQTFNKNVETYRNELTIRIPVKQA
AGGFDLAVTSQGCADAGICYPPMERVYHVSGAALLPAGSAAAPQSTANDAPWYERATSAD
YAQSLLQGGGFLAIIGLYFVAGIVLSLLPCSYPMIPILSAIIIGEGARVTRARGFALSLA
YVIGMALVYTALGIAAALVGQSLGAWLQNPWVLGAFGVLLTVFALTLIAGFDIALPQRWQ
DGASHASAGRSGGKFAAVAGMGALSALVVGACMTAPLFAVLAFIAHTGSAVLGGAALFAM
GLGLGVPLMIVGLGAGTLLPRAGAWMDDIKVLFGVVLLAAALWIVWPVLGATATMLLCAL
WLLIAAACVGLFSAPGVQASIWRRLGRGIGAALAVWAAVLLVGLAAGSSDPLRPLAVLAS
RSAAPAETSVAGAPQTASHDDLAFQAVRSSAELDGAVKAAAQPAMLDFYADWCVSCKEME
KFTFSDPRVQAKLKQMNLLRADVTANNADDQALLKRFGLFGPPGIIFFDRGGKEVLRVVG
YESADKFLRSLERASAPQT