Protein Info for ABIE53_003024 in Paraburkholderia graminis OAS925

Annotation: cardiolipin synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01066: CDP-OH_P_transf
  • amino acids 14 to 188 (175 residues), 131 bits, E=2.5e-42
• TIGR00560: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
  • amino acids 15 to 201 (187 residues), 176 bits, E=5.4e-56

Best Hits

KEGG orthology group: K00995, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase [EC: 2.7.8.5] (inferred from 98% identity to bgf:BC1003_2495)

Predicted SEED Role

"CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 2.7.8.5)

MetaCyc Pathways

• phosphatidylglycerol biosynthesis I (6/6 steps found)
• phosphatidylglycerol biosynthesis II (6/6 steps found)
• superpathway of phospholipid biosynthesis III (E. coli) (10/12 steps found)
• cardiolipin biosynthesis II (3/3 steps found)
• cardiolipin biosynthesis I (2/3 steps found)
• cardiolipin biosynthesis III (2/3 steps found)
• superpathway of cardiolipin biosynthesis (bacteria) (9/13 steps found)
• type I lipoteichoic acid biosynthesis (S. aureus) (5/17 steps found)
• superpathway of phospholipid biosynthesis II (plants) (10/28 steps found)

KEGG Metabolic Maps

• Glycerophospholipid metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.7.8.5

Use Curated BLAST to search for 2.7.8.5

Protein Sequence (208 amino acids)

>ABIE53_003024 cardiolipin synthase (Paraburkholderia graminis OAS925)
MQLSRQTLRLPMPFNFPIFLTWLRIVLIPLVVGVFYLPDMMMSPAHRNLAAATIFVLAAL
TDWFDGYLARKWNQTSAFGAFLDPVADKLMVTAALLVLVQLARIDSAIALVIVGREIAIS
ALREWMAQIGASKSVAVNSLGKFKTACQMVAIPMLLFNGVLPFGGGVAIDTRTWGLWLIY
LAAFLTIWSMLYYMKLAWPQIRERGGAV