Protein Info for ABIE53_001830 in Paraburkholderia graminis OAS925

Annotation: translation initiation factor IF-2

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1072 PF04760: IF2_N" amino acids 2 to 51 (50 residues), 27 bits, see alignment 7.5e-10 amino acids 406 to 456 (51 residues), 55.3 bits, see alignment 1.1e-18 PF08364: IF2_assoc" amino acids 61 to 99 (39 residues), 54.5 bits, see alignment (E = 2.6e-18) TIGR00487: translation initiation factor IF-2" amino acids 401 to 873 (473 residues), 700.2 bits, see alignment E=2.5e-214 TIGR00231: small GTP-binding protein domain" amino acids 485 to 641 (157 residues), 107.3 bits, see alignment E=7e-35 PF01926: MMR_HSR1" amino acids 487 to 592 (106 residues), 37.3 bits, see alignment E=6.8e-13 PF00009: GTP_EFTU" amino acids 487 to 642 (156 residues), 126.5 bits, see alignment E=2.5e-40 PF11987: IF-2" amino acids 758 to 872 (115 residues), 150.5 bits, see alignment E=4.6e-48

Best Hits

Swiss-Prot: 95% identical to IF2_PARXL: Translation initiation factor IF-2 (infB) from Paraburkholderia xenovorans (strain LB400)

KEGG orthology group: K02519, translation initiation factor IF-2 (inferred from 95% identity to bxe:Bxe_A2820)

Predicted SEED Role

"Translation initiation factor 2" in subsystem NusA-TFII Cluster or Translation initiation factors eukaryotic and archaeal or Universal GTPases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1072 amino acids)

>ABIE53_001830 translation initiation factor IF-2 (Paraburkholderia graminis OAS925)
MASNNVAQFAAELKMPAGVLLEQLQAAGVTKASEADSLSETDKARLLDHLRKSHGSTDAD
KRKITLTKRHTSEIKQSDATGKARTIQVEVRKKRTFVRRDETSAEGGEASNHVAEAPEVD
DLELQRREEEARHEAELLEKQAQELKARQEQLEREEAERQAREQAAEAERRRAEEEAAKK
RAAAAAEVTAREKVQQATQTAKVEAAAASAAEPAVAKDTEQDDERAAAERAAQREAAKKA
EDAARQAAEKARAEQEQIAKRRAAAEAEARAIREMMNTPRKAQVKAPEPAPKPAEPAKAA
EAKGTLHKPARPAGEAAARPAARKPATAAPAATTTTPSAGDKKKPGGKGGWQDDAAKRRG
IKTRGDTSGGVDRGWRGGPKGRGKHQDQNTTFQAPTEPIVREVHVPETITVADLAHKMAV
KASEVIKSMMKLGQMVTINQMLDQETAMIIVEELGHHAVAAKLDDPEAMLVEGEVSDAEA
LPRPPVVTVMGHVDHGKTSLLDYIRRAKVAAGEAGGITQHIGAYHVETPRGVITFLDTPG
HEAFTAMRARGAKATDIVILVVAADDGVMPQTKEAIAHAKAGGVPLVVAINKIDKPDANP
DRVKQELVAEGVVPEEYGGDSPFVSVSAKTGSGIDDLLENVLLQAEVLELKAPVEAPAKG
LVIEAKLDKGKGPVATILVQSGTLNRGDVVLAGSAYGRVRAMLDETGKPTKSAGPSIPVE
IQGLSEVPQAGEEVIVMPDERKAREVALFRQGKFRDVKLAKQQAAKLENMLEQMGEGEVQ
YMPLIVKADVQGSQEALVQSLLKLSTDEVRVQIVHGAVGGISESDVNLATASKAVIIGFN
TRADAQARKLAESNGVDIRYYNIIYDAVDEVKARDVGHAGSGEARSRDRYGRSSPGIQGA
EGRHGGRLYGHGRFREALVVGACAAQQRRHLHGRAGFAQALQGRREGSPSGLRVRYVGQE
LQRHRRRRSVRSLRGHRSRAYAVSHAARFQGRSGHQRPLRPLFLGRPVWGDPLGAARLGL
PLGAFRLGLFRFGPAASGAVSGAAARTPRFVRHAPAANHFLHPSQRITQHHA