Protein Info for ABIE53_001306 in Paraburkholderia graminis OAS925

Annotation: H+/Cl- antiporter ClcA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 490 transmembrane" amino acids 23 to 43 (21 residues), see Phobius details amino acids 59 to 77 (19 residues), see Phobius details amino acids 109 to 130 (22 residues), see Phobius details amino acids 162 to 186 (25 residues), see Phobius details amino acids 198 to 216 (19 residues), see Phobius details amino acids 234 to 257 (24 residues), see Phobius details amino acids 278 to 299 (22 residues), see Phobius details amino acids 320 to 342 (23 residues), see Phobius details amino acids 354 to 378 (25 residues), see Phobius details amino acids 384 to 410 (27 residues), see Phobius details PF00654: Voltage_CLC" amino acids 70 to 415 (346 residues), 281.7 bits, see alignment E=4.6e-88

Best Hits

KEGG orthology group: None (inferred from 92% identity to bug:BC1001_0808)

Predicted SEED Role

"Chloride channel protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (490 amino acids)

>ABIE53_001306 H+/Cl- antiporter ClcA (Paraburkholderia graminis OAS925)
MPRAQPFLSSGILRRGKRLWRQYGIFWLGAIAVGFVAVLYARLIDWGYDEFRAVQREHVW
APLIITPAVAALAVWLTRKFFRGAEGSGIPQVIATLHAKPGEYGARLLSFRILLGKIAVS
FLAILGGFTIGREGPTVQVGAALMFNLRRLYPRSNALIERQLVLAGAAAGLSAAFNTPLA
GIVFAIEELTRSFEARASGVLITAIIIAGVIALGLNGNYTYFGTIQIGAHFPNLLALAVL
LTAIVTGIAGGVFGWLLLNTARWIPAPLRRLHGERPVVFAALCGLVIAVVGIVSGGTTFG
SGYAEARGLLDGHEQLSVFYPFLKMISMVGSYLPGIPGGIFAPSLSIGAGFGNLLHMVFG
SMQLPMLIALAMVGYLAAVTQSPITSFVIVMEMINGHALVISLMATALIASRVSRMFAPA
LYEALSERYLAPLPRPAPAPVPEVPEVDAPEAAEASAAESSGEAPGNAPADVSADASTNA
PSEAPGKHTH