Protein Info for ABIE53_000799 in Paraburkholderia graminis OAS925

Annotation: 4-hydroxythreonine-4-phosphate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 336 TIGR00557: 4-hydroxythreonine-4-phosphate dehydrogenase PdxA" amino acids 13 to 330 (318 residues), 409 bits, see alignment E=8.2e-127 PF04166: PdxA" amino acids 45 to 326 (282 residues), 357.6 bits, see alignment E=2.7e-111

Best Hits

Swiss-Prot: 83% identical to PDXA_BURVG: 4-hydroxythreonine-4-phosphate dehydrogenase (pdxA) from Burkholderia vietnamiensis (strain G4 / LMG 22486)

KEGG orthology group: K00097, 4-hydroxythreonine-4-phosphate dehydrogenase [EC: 1.1.1.262] (inferred from 94% identity to bgf:BC1003_0401)

Predicted SEED Role

"4-hydroxythreonine-4-phosphate dehydrogenase (EC 1.1.1.262)" in subsystem Pyridoxin (Vitamin B6) Biosynthesis (EC 1.1.1.262)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.262

Use Curated BLAST to search for 1.1.1.262

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (336 amino acids)

>ABIE53_000799 4-hydroxythreonine-4-phosphate dehydrogenase (Paraburkholderia graminis OAS925)
MNTAAQSARLPLQIAITTGEPAGVGPELTAQALAGAAAHWPGAQFTVLGDSTLLAERARA
VGVDWSALAAQAGRISVQHRPLGAPAVAGKLNAANGRYVLDLLDSAIDGAMAGTFDAIVT
APLQKSTINDAGVPFTGHTEYLAERTHTPRVVMMLAGTGKRPLRVALATTHLPLKDVSAA
LTQQGLVETLRIVDHDLRHHFGLPAPRILVTGLNPHAGENGYLGREEIDVISPALKLANG
EGIDARGPYPADTLFQPRYLDEADCVLAMFHDQGLPVLKYATFGEGINITLGLPIIRTSV
DHGTALDLAGTGRADAGSLIAAIDTAVSMAQHRRAG