Protein Info for ABIE53_000167 in Paraburkholderia graminis OAS925

Annotation: thiol:disulfide interchange protein DsbD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 624 signal peptide" amino acids 1 to 41 (41 residues), see Phobius details transmembrane" amino acids 208 to 234 (27 residues), see Phobius details amino acids 247 to 277 (31 residues), see Phobius details amino acids 283 to 305 (23 residues), see Phobius details amino acids 329 to 356 (28 residues), see Phobius details amino acids 366 to 388 (23 residues), see Phobius details amino acids 397 to 418 (22 residues), see Phobius details amino acids 424 to 444 (21 residues), see Phobius details amino acids 461 to 481 (21 residues), see Phobius details PF11412: DsbD_N" amino acids 44 to 156 (113 residues), 99.4 bits, see alignment E=4.5e-32 PF02683: DsbD" amino acids 211 to 412 (202 residues), 65.7 bits, see alignment E=1.7e-21 PF13386: DsbD_2" amino acids 211 to 412 (202 residues), 36 bits, see alignment E=2.2e-12 PF13899: Thioredoxin_7" amino acids 523 to 595 (73 residues), 40 bits, see alignment E=1.1e-13 PF13098: Thioredoxin_2" amino acids 526 to 619 (94 residues), 40.5 bits, see alignment E=9e-14

Best Hits

KEGG orthology group: K05905, protein-disulfide reductase [EC: 1.8.1.8] (inferred from 71% identity to bvi:Bcep1808_7178)

Predicted SEED Role

"Cytochrome c-type biogenesis protein DsbD, protein-disulfide reductase (EC 1.8.1.8)" in subsystem Biogenesis of c-type cytochromes or Periplasmic disulfide interchange (EC 1.8.1.8)

Isozymes

Compare fitness of predicted isozymes for: 1.8.1.8

Use Curated BLAST to search for 1.8.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (624 amino acids)

>ABIE53_000167 thiol:disulfide interchange protein DsbD (Paraburkholderia graminis OAS925)
MQTTSLFAQRGICRLASMLNRMLRVALGLLFILTSLAAHAVNESDLLPPERAFPLRVTSG
GPQQVVLDFDTQPGYYLYRDRFSFAVDGTSIKPEQMPPGELKNDPTFGMVTVYHHPVQIY
VSLPRPVATSVVLSVTSQGCADIGVCYPPQTRNYRVSADGSVTSVTAPSSAPAANSGLPG
VGESQSPAAAPPGMNLHPANGISVPELLGFLFAGLLMAGTVCMYPLIPIVTAVIGGTQQR
RSLGRGFLLSFAYVQGLAITYAVAGTIAALIGIPLVAVTQKPWVLAGFGVLMVIFALGMF
GVFRLQLPAGWQTRITEWGNRLPGGRTVPVFMMGMLAALIVGPCSTPALAGALLYIANSH
DVAGGALALYVMGLGIGIPLLLVGTFGAHILPRSGHWMVAVQNVLGVMLLAAALWFVYSL
LPTWLLMVLVALLLTGCGTMLRAIDPLPPDASGISRVAKAMGVLLLVAGVAEFIGVAAGN
FDVLTPLGGLMRTSSSARGETEARPTANFEAIRSNAELDHALTSASGQPVMVDFYADWCI
SCKELERFTFTDRRVVSEFAHWKLLRIDVTKNTAEDTAMLRRFGLFGPPALIFYNRSGQQ
QPDAQLAGFVGADAFLAHLKRWRG