Protein Info for ABIE51_RS17980 in Lysobacter sp. OAE881

Annotation: multidrug efflux RND transporter permease subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1055 signal peptide" amino acids 9 to 11 (3 residues), see Phobius details transmembrane" amino acids 12 to 30 (19 residues), see Phobius details amino acids 340 to 359 (20 residues), see Phobius details amino acids 366 to 387 (22 residues), see Phobius details amino acids 393 to 414 (22 residues), see Phobius details amino acids 437 to 458 (22 residues), see Phobius details amino acids 470 to 497 (28 residues), see Phobius details amino acids 538 to 556 (19 residues), see Phobius details amino acids 873 to 892 (20 residues), see Phobius details amino acids 899 to 919 (21 residues), see Phobius details amino acids 925 to 950 (26 residues), see Phobius details amino acids 971 to 991 (21 residues), see Phobius details amino acids 1002 to 1027 (26 residues), see Phobius details TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 1 to 1041 (1041 residues), 1434.3 bits, see alignment E=0 PF00873: ACR_tran" amino acids 1 to 1028 (1028 residues), 1187.2 bits, see alignment E=0 PF03176: MMPL" amino acids 340 to 496 (157 residues), 25.1 bits, see alignment E=8.1e-10 amino acids 834 to 1027 (194 residues), 21 bits, see alignment E=1.4e-08

Best Hits

Swiss-Prot: 54% identical to ACRF_ECOLI: Multidrug export protein AcrF (acrF) from Escherichia coli (strain K12)

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 75% identity to sml:Smlt3171)

MetaCyc: 54% identical to multidrug efflux pump RND permease AcrF (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-352; TRANS-RXN-354; TRANS-RXN-355; TRANS-RXN-367

Predicted SEED Role

"RND efflux system, inner membrane transporter CmeB" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1055 amino acids)

>ABIE51_RS17980 multidrug efflux RND transporter permease subunit (Lysobacter sp. OAE881)
MSRFFINHPVFAWVIAILISLCGVLAILNLGVESYPSIAPPQVTVSASYPGASAETAEGA
VTQVIEQQLTGIDNLVYFSSSSSSSGGSNITLTFAPGTDPDIAQVQVQNKVALATPRLPT
EVTQQGVVVAKANAGFLKVVALRSDDESMDRDALSDIIASRVLDQIARVPGVGSTQLFGS
EYAMNIWLNPDRLRGFGLSATQVLQAVRSQNVQFAAGKIGADPAPVEQGFTATVSAEGRF
STPEQFGNIILRTNTDGTSVRLRDVARVGLGATSYGFDSRWDGKPAAGFAIQLAPGANAL
GVAEAVTKRMNELQATFPKGVTWFSPYDSSTFVAVSIKEVIKTLFEAIVLVFLVMLIFLQ
NLRATLIPTLVIPIALLGTFLGMYFIGFTINQLSLFGMVLAIGIVVDDAIVVIENVERIM
TEEGLSPKAATRKSMSQISGAVVAITVVLAAVFIPSAFQGGSAGEIYKQFAITIAMAMFF
SAFLALGFTPALCATLLKPTADHHRDNIVFRTFNKYYDKIAKTYVGHIGHAISHAPRWMM
VFGVLVVLAGFLFTRMPGSFLPEEDQGYAIALINLPAGATINRTNAVLDQVRETVAKDDA
FDGIFTVAGFSFVGQGENVGIAFIRLKPWDDRKVTASEFIQKANMALFGIRDAQIFVINL
PTVSGLGQFGGFDMYLQDRSGQGRAALTEARNTLLGKAAQDKALTGVRPNELEAAPQLRL
DVDRVQAQSMGLSVGDIYSAIQLMLAPVYVNDFVDEGRVKRVTMQADAPYRTGPESLTRF
YTPSPLTQAAPGEATSMVPLSNIVRSHWITASPSLTRYNGYAAVEIVGSQAPGHSSGEAM
TAMQNIVEKDLPQGFGYDWTGQSYQEILSGNQAPALLALSILVVFLCLAALYESWSVPVA
VLLVVPLGALGAVLFSLLRGLPNDIYFKIGLITVIGLAAKNAILIVEFAIEQRQHGKTLR
EATIEAAHLRFRPILMTSFAFIMGVFPLAISSGAGANSRHAIGTGVIGGMIFATFLGLLL
IPVFYVAVRRLLGDKMDEKPVIEHDDEEPTPRPAT