Protein Info for ABIE51_RS13675 in Lysobacter sp. OAE881
Annotation: diaminopimelate decarboxylase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 45% identical to DCDA_NEIMB: Diaminopimelate decarboxylase (lysA) from Neisseria meningitidis serogroup B (strain MC58)
KEGG orthology group: K01586, diaminopimelate decarboxylase [EC: 4.1.1.20] (inferred from 51% identity to azl:AZL_d01130)Predicted SEED Role
"Diaminopimelate decarboxylase (EC 4.1.1.20)" in subsystem Lysine Biosynthesis DAP Pathway (EC 4.1.1.20)
MetaCyc Pathways
- L-lysine biosynthesis I (8/9 steps found)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (14/18 steps found)
- aspartate superpathway (19/25 steps found)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (11/15 steps found)
- L-lysine biosynthesis III (5/7 steps found)
- L-lysine biosynthesis VI (5/7 steps found)
- L-lysine biosynthesis II (6/9 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 4.1.1.20
Use Curated BLAST to search for 4.1.1.20
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (413 amino acids)
>ABIE51_RS13675 diaminopimelate decarboxylase (Lysobacter sp. OAE881) MSNFLPGELGAIARQIQTPFYAYSAQMIRDRIASLHGAFRGVDVRICFAVKANSNIAILQ LMAQHGVGADIVSLGEMQRSLKSGIPAERIVFSGVGKTADEIDAALAAGVWRFNVESADE LHLLQHRAQSRGVCARAAVRINPDVDARTHAKISTGKAENKFGVSIDEARRWFADCASLD HVQLDGLHAHIGSQILDLEPFRQALQRVEAFRRELVQSGHAIASVDIGGGLGVMYRPGVD MPVDIAAYASLVRATFADFKGTLALEPGRWLVAEAGVLVTRAIRVKHGTDRQFLVVDVAM NDLLRPSLYDAWHEIVPMHGRDEPEVAYDVVGPVCETGDTFAHGRVLARCESGDLLMIGG AGAYGASMGSTYNSRPLPPEVLLDDGRYAIIRRRQTITEMMAGEQFPQAWHET