Protein Info for ABIE51_RS08115 in Lysobacter sp. OAE881

Annotation: pyroglutamyl-peptidase I

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 59% identical to PCP_CITK8: Pyrrolidone-carboxylate peptidase (pcp) from Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)

KEGG orthology group: K01304, pyroglutamyl-peptidase [EC: 3.4.19.3] (inferred from 60% identity to spe:Spro_1260)

Predicted SEED Role

"Pyrrolidone-carboxylate peptidase (EC 3.4.19.3)" in subsystem ZZ gjo need homes (EC 3.4.19.3)

MetaCyc Pathways

5-oxo-L-proline metabolism (5/6 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.19.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (219 amino acids)

>ABIE51_RS08115 pyroglutamyl-peptidase I (Lysobacter sp. OAE881)
MNATPMPHVLLTGFAPFGGESTNPSWEAVQALEGEVVAGHRIVARCLPVAFDASLHALQH
ALDELVPSLVICVGQAGGRAQMSLERVAINLIDARIPDNAGAQPIDEPVAADGPAAYFTS
LPIKAMLAALRNAGFPAEISQTAGTYVCNHVFYALMHALRGLPGVRGGFVHIPYSPAQAA
LHAGAPSLPSAVVTQALRLAVGIALTVEHDVRMGGGATH