Protein Info for ABIE51_RS07835 in Lysobacter sp. OAE881

Annotation: Vi polysaccharide biosynthesis UDP-N-acetylglucosamine C-6 dehydrogenase TviB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03026: nucleotide sugar dehydrogenase
  • amino acids 17 to 421 (405 residues), 378.2 bits, E=2.2e-117
• PF03721: UDPG_MGDP_dh_N
  • amino acids 17 to 189 (173 residues), 108.6 bits, E=4.3e-35
• PF00984: UDPG_MGDP_dh
  • amino acids 212 to 300 (89 residues), 84.9 bits, E=5.1e-28
• PF03720: UDPG_MGDP_dh_C
  • amino acids 327 to 425 (99 residues), 75.3 bits, E=6.7e-25

Best Hits

Swiss-Prot: 60% identical to VIPA_SALTI: Vi polysaccharide biosynthesis protein VipA/TviB (vipA) from Salmonella typhi

KEGG orthology group: K02474, UDP-N-acetyl-D-galactosamine dehydrogenase [EC: 1.1.1.-] (inferred from 71% identity to alv:Alvin_2213)

MetaCyc: 68% identical to UDP-N-acetylgalactosamine 6-dehydrogenase (Pseudomonas aeruginosa)
UDP-N-acetylglucosamine 6-dehydrogenase. [EC: 1.1.1.136]; 1.1.1.136 [EC: 1.1.1.136]

Predicted SEED Role

"UDP-glucose dehydrogenase (EC 1.1.1.22)" in subsystem Lipid A-Ara4N pathway ( Polymyxin resistance ) or Teichuronic acid biosynthesis (EC 1.1.1.22)

MetaCyc Pathways

• UDP-α-D-xylose biosynthesis (2/2 steps found)
• UDP-α-D-glucuronate biosynthesis (from UDP-glucose) (1/1 steps found)
• colanic acid building blocks biosynthesis (8/11 steps found)
• superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis (4/6 steps found)
• UDP-N-acetyl-α-D-galactosaminuronate biosynthesis (1/2 steps found)
• UDP-2,3-diacetamido-2,3-dideoxy-α-D-mannuronate biosynthesis (1/5 steps found)
• UDP-sugars interconversion (3/9 steps found)
• teichuronic acid biosynthesis (B. subtilis 168) (2/9 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (6/24 steps found)

KEGG Metabolic Maps

• Alkaloid biosynthesis I
• Aminosugars metabolism
• Ascorbate and aldarate metabolism
• Benzoate degradation via CoA ligation
• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of type II polyketide products
• Biosynthesis of unsaturated fatty acids
• Bisphenol A degradation
• Butanoate metabolism
• C21-Steroid hormone metabolism
• Fructose and mannose metabolism
• Glycine, serine and threonine metabolism
• Insect hormone biosynthesis
• Linoleic acid metabolism
• Nucleotide sugars metabolism
• Pentose and glucuronate interconversions
• Polyketide sugar unit biosynthesis
• Retinol metabolism
• Starch and sucrose metabolism
• Tetrachloroethene degradation

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.-, 1.1.1.22

Use Curated BLAST to search for 1.1.1.- or 1.1.1.136 or 1.1.1.22

Protein Sequence (434 amino acids)

>ABIE51_RS07835 Vi polysaccharide biosynthesis UDP-N-acetylglucosamine C-6 dehydrogenase TviB (Lysobacter sp. OAE881)
MHDEPGVAALPTLDTVRLGVVGLGYVGLPLAVAFGRRFDTVGFDINAQRVVELREGRDST
LEVDADELAQAKRLRCSSDLGMLQRCNVYIVTVPTPIDAAKRPDLGPLVRASEALGQVLK
RGDVVVYESTVYPGCTEEVCVPILERASGLVFNRDFFAGYSPERINPGDKEHRLTRILKI
TSGSTPRAADFVDALYGSIIEAGTHKASSIKVAEAAKVIENTQRDLNIALVNDLAILFNK
LGIDTLEVLQAAGTKWNFLPFRPGLVGGHCIGVDPYYLTHKAQEIGHHPDVILAGRRTND
GMGAYIASEVVRLMVRRGINPVQARILVLGLAFKENCPDLRNTRVVDIVHALRGYNAQVD
VHDPWVNAHDASHEYGLAMNGAPEHGSYDAVIVAVAHREFAQLGADGVRAYGKPTSIVYD
VKYVLPRDAVDGRL