Protein Info for ABIE51_RS07785 in Lysobacter sp. OAE881

Annotation: DNA mismatch repair protein MutS

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 858 transmembrane" amino acids 630 to 649 (20 residues), see Phobius details TIGR01070: DNA mismatch repair protein MutS" amino acids 10 to 855 (846 residues), 1121.5 bits, see alignment E=0 PF01624: MutS_I" amino acids 11 to 122 (112 residues), 148 bits, see alignment E=3.1e-47 PF05188: MutS_II" amino acids 132 to 255 (124 residues), 104 bits, see alignment E=2.2e-33 PF05192: MutS_III" amino acids 272 to 561 (290 residues), 173.3 bits, see alignment E=2e-54 PF05190: MutS_IV" amino acids 430 to 521 (92 residues), 104.2 bits, see alignment E=9e-34 PF00488: MutS_V" amino acids 612 to 799 (188 residues), 284.1 bits, see alignment E=1.5e-88

Best Hits

Swiss-Prot: 81% identical to MUTS_XANCP: DNA mismatch repair protein MutS (mutS) from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)

KEGG orthology group: K03555, DNA mismatch repair protein MutS (inferred from 80% identity to psu:Psesu_1011)

MetaCyc: 56% identical to DNA mismatch repair protein MutS (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"DNA mismatch repair protein MutS" in subsystem DNA repair, bacterial MutL-MutS system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (858 amino acids)

>ABIE51_RS07785 DNA mismatch repair protein MutS (Lysobacter sp. OAE881)
MSQAERPQEHTPLMKQFFAAKAEHPDVLLFFRMGDFYELFFDDARKAARLLDITLTQRGQ
SAGQPIPMAGVPHHSAEGYLARLVALGESVAICEQIGDPALAKGIVERKVVRIVTPGTVT
DEALLNERRDTLLLAVARGKNGYGIAWADLAGGRFLVNEVANEDALEAEIARLEPAETLI
ADEDGWQPWIAERTGVRRRAPWLFDADSGRRQLLRFFNLHDLSGFGLEDKPLSTAAAAAL
LGYVEETQKQRLPHLTSIAVESGDGAIAMNAATRRHLELDTRVDGDTRHTLLGILDSTIT
PMGGRLLRRWLHRPLRDRSVLRHRQQAVATLIESRCGDTLRESFRALGDLERILSRIALR
SARPRDLSTLRDGLNMLPDVRTLLAPLDSPCLAELAAELGEHDDHAHLLKSAIVPQPPVL
ARDGGIFAEGYDAELDELRTLSTNADQFLIDLEAREKAATGIATLKVGYNRVHGYYIEIS
KGQSDKAPTHYTRRQTLTGAERYITEELKQFEDKVLSARERSLARERLLYEQLLDALNER
LQPLKRCAAALAELDVLACFAERAQSLDWSQPQLVDEPGICIERGRHPVVEAVRNDPFEP
NDLVLDESRRMLVITGPNMGGKSTYMRQNALIVLLAHIGSFVPAARAVIGPIDRILTRIG
AGDDLARGQSTFMVEMSETSYILHHATSQSLVLMDEIGRGTSTYDGLALADACARHLAHH
NRAYTLFATHYFELTRLAEPGSGIANVHLDAVEHGDQLVFMHAVKDGPADRSFGLQVAAL
AGLPKAVVQQARGRLAELEQQSRDAPTPSLAPVALDAPQQFGLFAPSSAALDALASIDPD
DLTPKQALEALYRLKALG