Protein Info for ABIE51_RS03820 in Lysobacter sp. OAE881

Annotation: heavy metal translocating P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 801 transmembrane" amino acids 179 to 201 (23 residues), see Phobius details amino acids 215 to 236 (22 residues), see Phobius details amino acids 248 to 266 (19 residues), see Phobius details amino acids 276 to 294 (19 residues), see Phobius details amino acids 429 to 449 (21 residues), see Phobius details amino acids 460 to 480 (21 residues), see Phobius details amino acids 747 to 764 (18 residues), see Phobius details amino acids 770 to 789 (20 residues), see Phobius details PF12156: ATPase-cat_bd" amino acids 18 to 87 (70 residues), 41.4 bits, see alignment E=5.2e-14 PF00403: HMA" amino acids 102 to 158 (57 residues), 34.7 bits, see alignment 4.7e-12 TIGR01511: copper-translocating P-type ATPase" amino acids 232 to 790 (559 residues), 448 bits, see alignment E=1.2e-137 TIGR01525: heavy metal translocating P-type ATPase" amino acids 250 to 790 (541 residues), 480.9 bits, see alignment E=1.3e-147 TIGR01512: cadmium-translocating P-type ATPase" amino acids 278 to 791 (514 residues), 368.7 bits, see alignment E=9.1e-114 TIGR01494: HAD ATPase, P-type, family IC" amino acids 285 to 769 (485 residues), 239.6 bits, see alignment E=1e-74 PF00122: E1-E2_ATPase" amino acids 321 to 489 (169 residues), 162.7 bits, see alignment E=1.7e-51 PF00702: Hydrolase" amino acids 507 to 702 (196 residues), 87 bits, see alignment E=5.8e-28

Best Hits

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 64% identity to psu:Psesu_0336)

Predicted SEED Role

"Type cbb3 cytochrome oxidase biogenesis protein CcoI; Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.4)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.4

Use Curated BLAST to search for 3.6.3.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (801 amino acids)

>ABIE51_RS03820 heavy metal translocating P-type ATPase (Lysobacter sp. OAE881)
MDAALPLRDTRTADIGVCHHCGETLAADAICDGDRAFCCNGCAAAATWIREAALGDYYAL
RTSPAGRVQVDASDFGAWDRDVVLAEHARVVPGGREITVLTDAMRCAACAWLIDRALRRH
PGVLDAGANAVTGRVVVAWDPQRVTLSTLMQRLAALSYRPWLATGDAREQAQRRERRRWL
LRLGVAGLGAIQAMMFAEALYLDTAQQMPVATRDFFRWITFLVSTPVVFYSGWPFLEGMW
RELRGRRVGMDTLIAGSTLLAYVASLAETLRGGTHVWYDAAVMFVLLLLVARMFEQRARG
IASAQVDALARARPALALREREDGSTEQVPLGEIAIGDVLRVAAGEAVPADGVLLDRAAS
FDEALITGESTPVRREAGDAALAGSVCGEHAARLRVVRTGADTRLSQLTRLVEQAQSARP
RLARAAERVAGGFVVALLLCAVATLAWWHVHEPARALEVTLALLVVSCPCALSLAIPTAL
TTAHGALARIGVLGVREDALSTLARVDRVVLDKTGTLSNGRPELDSIATFVDLDARDALS
IASALERGSAHPLAQAFAHTAADRTAHGVQAVAGCGIEGDIEGVRWRLGRADFAARQADD
GALWLGDGTRAFARITVRETMRDGAREAITALREAGIAVELCSGDATEAVASFARQVGID
DVLARQSPEQKLARVREAQSRGDVVAMVGDGINDAPVLAGADVSLAMAEGAALAQRAADF
VVTSPSLLRVPQAIALARRTQRIIRQNLAWALGYNVLAIPLAATGHVTPWIAALGMAGSS
LLVTLNALRLSRGQRNGRRAA