Protein Info for ABIE51_RS00895 in Lysobacter sp. OAE881

Annotation: acetyl-CoA hydrolase/transferase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02550: AcetylCoA_hydro
  • amino acids 10 to 221 (212 residues), 105.3 bits, E=4.5e-34
• TIGR03458: succinate CoA transferase
  • amino acids 11 to 501 (491 residues), 805.9 bits, E=5.8e-247
• PF13336: AcetylCoA_hyd_C
  • amino acids 325 to 468 (144 residues), 150.1 bits, E=5e-48

Best Hits

Swiss-Prot: 59% identical to SCACT_ACEAC: Succinyl-CoA:acetate CoA-transferase from Acetobacter aceti

KEGG orthology group: None (inferred from 72% identity to sml:Smlt0471)

MetaCyc: 59% identical to succinyl-CoA:acetate CoA-transferase monomer (Acetobacter aceti)
RXN-8807 [EC: 2.8.3.18]

Predicted SEED Role

"Acetyl-CoA hydrolase (EC 3.1.2.1)" (EC 3.1.2.1)

MetaCyc Pathways

• pyruvate fermentation to acetate V (3/3 steps found)
• superpathway of anaerobic energy metabolism (invertebrates) (13/17 steps found)
• TCA cycle VII (acetate-producers) (7/9 steps found)
• acetate formation from acetyl-CoA (succinate) (1/1 steps found)
• pyruvate fermentation to acetate VI (2/3 steps found)
• anaerobic energy metabolism (invertebrates, mitochondrial) (6/10 steps found)
• succinate fermentation to butanoate (1/7 steps found)

KEGG Metabolic Maps

• Pyruvate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.8.3.18 or 3.1.2.1

Protein Sequence (503 amino acids)

>ABIE51_RS00895 acetyl-CoA hydrolase/transferase family protein (Lysobacter sp. OAE881)
MNDRIRHAGLRDKRMSAENAAALIQPGMTVAMSGFTGAGYPKSVPQALATRIEQAHARGE
DFRVKVMTGASTAPELDGVLARAQGIELRLPYQSDPHLRERINAGDLHYIDMHLSHVAQH
TWFGFFGAVDVAVIEVTAITEDGHLVPSSSVGNNKTWLEQADRVILEVNRWQPAALEGMH
DVYYGTALPPNRKPIRLLHPDDRIGEPWLRCDPSKVIAVVETDAPDRNSPFTPPDATSRE
IAAHLLDFLTHEVRRGRLQPQLLPLQSGVGNITNAVLMGLGEAGYRDLTAFTEVIQDGML
DLLKRGVVRVASATSFSLSPAAIDEFLDRVDYYRERIVLRTQEISNHPELVRRLGCIAMN
GMIEVDLYGNVNSTHVAGTKIMNGIGGSGDFARNAYLSVFMSPSTAKNGAISSIVPMASH
VDHTEHDVMVIVTERGIADLRGLSPKQRAQRMIDGCAHPDYQPMLQDYFDRACRGSFGKH
TPHLLGEALSWHQRFVETGSMRK