Protein Info for ABIE51_RS00185 in Lysobacter sp. OAE881

Annotation: GGDEF domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 PF00027: cNMP_binding" amino acids 47 to 131 (85 residues), 61 bits, see alignment E=9.3e-21 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 184 to 342 (159 residues), 114.3 bits, see alignment E=2.4e-37 PF00990: GGDEF" amino acids 187 to 339 (153 residues), 125.3 bits, see alignment E=2e-40

Best Hits

KEGG orthology group: None (inferred from 64% identity to psu:Psesu_0140)

Predicted SEED Role

"cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases" in subsystem cAMP signaling in bacteria

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (350 amino acids)

>ABIE51_RS00185 GGDEF domain-containing protein (Lysobacter sp. OAE881)
MTRDSAASLRTRDSINSGKYGSAPADVATAVLTEAEYELFAELGRPRRVEAGQLLFRRGE
LGTTMFVIARGVVDLDFGDDLVGKRLGPSEFFGELGLLIGDHVRSADAVAASDGLLIELR
HEEFQRLVDRDPGLVSYFLRRAILRVVLNEQSLIRRLRRRNEELQSALDSLYAATHQLNQ
TEELVRTDELTRLYNRRALTLHLQERRELGEQRSMGLLLVDCDRFKQVNDDHGHLIGDRV
LQGVANILRSVAGPEDLACRIGGDEFCLLVVSDQREEVMRFGDFIVSTAQGLMQMSHGTP
LMCPLSVGACLIDPARDWNDGYAHADAALYQAKRLGGNRVHWHDMELTSA