Protein Info for ABCV34_RS14620 in Castellaniella sp019104865 MT123
Annotation: multidrug efflux RND transporter permease subunit
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 61% identical to MDTB_ECO81: Multidrug resistance protein MdtB (mdtB) from Escherichia coli O81 (strain ED1a)
KEGG orthology group: K07788, RND superfamily, multidrug transport protein MdtB (inferred from 70% identity to bbr:BB4431)MetaCyc: 61% identical to multidrug efflux pump RND permease subunit MdtB (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-352; TRANS-RXN-353; TRANS-RXN-92
Predicted SEED Role
"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (1027 amino acids)
>ABCV34_RS14620 multidrug efflux RND transporter permease subunit (Castellaniella sp019104865 MT123) MNLSRPFILRPIATTLAMIAVVLAGLLGYRELPVSALPQVDFPTIQVTTLYPGAGPDVMT ALVTSPLERQFGQMPGLSQMLSTSSGGSSRITLRFDLGLPLDVAEQEVQAAINAASNLLP GDMPSPPIYRKVNPADTPVMTLAVTSPTLPLDQVRDLIEVRVAQKLSQISGVGLVSVTGG QRPAVRIQVDPQALAAHKLTLADVRKAVTQSNVNQPKGNLDGPQRSLTISVNDQLKDPAE YERLILAYENGAPLRLGDVAHVRRAAENLYQAAWFDHTPAVLLNIQRQPGANVIQVVDQI QTLLPGLRQTLPTGVDLRVAADRTHTIRDSIDHVQIEMLLAIALVVAVTFVFLRTWRATL IPGVVVPLSLVGTFGLMYLMGFSINNLTLMALTIATGFVVDDAIVMIENIARHIEEGENA LTAALRGARQIGFTLVSLTVSLIAVLIPLLFMADVVGRLFREFAVTLAVAILLSLLISLT LTPMMCARMLRPESEERHGRFLRGAGRAMDRLVTAYDRGLTWVLAHQLATLWFALGTLVV TVGLYAGIPKGFFPQQDTGAIQAITQGPQTASFPVMSRLQQSAVERVLADPAVASVTSFI GIDGDNTTLNTGRLQITLKPLTERRVRADAVIDRLNQALHAVVGLQVWLQPVQELSVEDQ ISRAQFQMTVSSPNDAALALWAPRLIETLQRLPQLRAVAGDLQDHGLALNVQVDRDAAAR LGVTQAAIDDALYDAFGQRLISTIYTQSAQYRVVLEAGAAQLDGGPQALAHIHVPTAGGG VTPLSTVARFVPGVTRLAVQRLDQFPATTVSFNLAPGVALSDAVQAIEGARVSLGVPDSV EIQFQGAARAFQASLSSTLLLLLAAVVTMYIVLGVLYESLIHPVTILSTLPSAAVGALLA LWAGGVELDMIGVIGIILLIGIVKKNAILMIDFALDAQRERGLGPQAAIHEAALLRFRPI LMTTLAAFFSAIPLMFASGSGAELRQPLGLAMVGGLLCSQLLTLFTTPVIYLMFERLAHR RTAPDRS