Protein Info for DvMF_2835 in Desulfovibrio vulgaris Miyazaki F

Name: dnaK
Annotation: molecular chaperone DnaK (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 639 TIGR02350: chaperone protein DnaK" amino acids 3 to 598 (596 residues), 981.7 bits, see alignment E=5.7e-300 PF00012: HSP70" amino acids 4 to 598 (595 residues), 887.8 bits, see alignment E=3.2e-271 PF06723: MreB_Mbl" amino acids 135 to 370 (236 residues), 48.7 bits, see alignment E=5.2e-17

Best Hits

Swiss-Prot: 100% identical to DNAK_DESVM: Chaperone protein DnaK (dnaK) from Desulfovibrio vulgaris (strain Miyazaki F / DSM 19637)

KEGG orthology group: K04043, molecular chaperone DnaK (inferred from 100% identity to dvm:DvMF_2835)

MetaCyc: 62% identical to chaperone protein DnaK (Escherichia coli K-12 substr. MG1655)
Non-chaperonin molecular chaperone ATPase. [EC: 3.6.4.10, 5.6.1.7]

Predicted SEED Role

"Chaperone protein DnaK" in subsystem Heat shock dnaK gene cluster extended or Protein chaperones

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.4.10 or 5.6.1.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8DRD6 at UniProt or InterPro

Protein Sequence (639 amino acids)

>DvMF_2835 molecular chaperone DnaK (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MGKIIGIDLGTTNSCVYVMEGKDPKCITNPEGGRTTPSIVAFTDKERLVGDIAKRQAVTN
PERTVFAVKRLMGRKGDAPEVNNWKTHSPYRIVAGANGDAAVEVQGRQYSAAEVSAMILG
KLKADAEAYLGETVTDAVITVPAYFNDAQRQATKDAGRIAGLDVKRIINEPTAASLAYGF
DRKTNEKIAVFDLGGGTFDISILEVGDNVVEVRATNGDTFLGGEDFDQRVINYLVEEFRR
ENGVDLSKDRMALQRLKEAAEKAKKDLSTSMETEINLPFITADQNGPKHLMMKLSRAKLE
KLVEDLVDRTIEPCRKALADAGLSAAQIDEVVLVGGMTRMPLVQKKVGEFFGKEPNRSVN
PDEVVAMGAAIQGGILAGDVKDVLLLDVTPLSLGIETLGGVFTRLIDRNTTIPTRKSQTF
TTAADNQPSVSIHVLQGERPMAGDNMTLGRFELSGIPPAMRGTPQVEVTFDIDANGIVNV
SAKDLGTGKEQSIRITASSGLSESEIQRLIKEAESHADEDKKKQELIEARNQADGLIYGT
EKSIADLGDKLDAATKSDIEGKIEALKKVMDGSDLEAIKTASEELSRASHKLAEQLYQQS
QQGQPGAGPEAGDAGHAGHAGSAKGDDDVVDADYTEVKK