Protein Info for DvMF_2580 in Desulfovibrio vulgaris Miyazaki F

Annotation: S-adenosyl-L-homocysteine hydrolase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 100% identical to SAHH_DESVM: Adenosylhomocysteinase (ahcY) from Desulfovibrio vulgaris (strain Miyazaki F / DSM 19637)

KEGG orthology group: K01251, adenosylhomocysteinase [EC: 3.3.1.1] (inferred from 100% identity to dvm:DvMF_2580)

Predicted SEED Role

"Adenosylhomocysteinase (EC 3.3.1.1)" in subsystem Methionine Biosynthesis or Methionine Degradation (EC 3.3.1.1)

MetaCyc Pathways

S-adenosyl-L-methionine salvage II (3/3 steps found)
L-methionine degradation I (to L-homocysteine) (2/3 steps found)
superpathway of L-cysteine biosynthesis (mammalian) (2/5 steps found)
superpathway of L-methionine salvage and degradation (5/16 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.3.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8DR41 at UniProt or InterPro

Protein Sequence (479 amino acids)

>DvMF_2580 S-adenosyl-L-homocysteine hydrolase (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MTDAKRAQALDLSLANKVADMALADFGHKEMQLSEREVPGLMELIRMYGVSKPLKGLRVT
GSLHMTIQTAMLIKTLYELGADIRWASCNIFSTQDHAAAAIADSGMAKVFAWKGETLEDY
WWCTEMALTWPDGSGPDLLVDDGGDATLMIHKGVEVENNPELLKQAYDNKEFQIIMDRLA
LAYQNDPGRWQRVAARVRGVSEETTTGVHRLYQLEQEGKLLFPAINVNDSVTKSKFDNLY
GCRESLADGIKRATDVMVAGKVVVVAGYGDVGKGCAQSMRGFGARVLVTEIDPICALQAA
MEGYEVTTMEKAVEEGDIFVTATGNYKVITGEHMEAMKDEAIVCNIGHFDNEIDMHYLET
TPGCTCLNIKPQVDKWTLKSGRSIIVLAEGRLVNLGCATGHPSFVMSNSFTNQTLAQIEL
ATNPDLERKVYILPKKLDEQVARLHLARLGVTLTTLTKEQADYIGVPVDGPYKPGHYRY