Protein Info for DvMF_2066 in Desulfovibrio vulgaris Miyazaki F

Annotation: heavy metal translocating P-type ATPase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 838 transmembrane" amino acids 183 to 203 (21 residues), see Phobius details amino acids 217 to 238 (22 residues), see Phobius details amino acids 254 to 281 (28 residues), see Phobius details amino acids 293 to 310 (18 residues), see Phobius details amino acids 436 to 459 (24 residues), see Phobius details amino acids 466 to 466 (1 residues), see Phobius details amino acids 468 to 494 (27 residues), see Phobius details amino acids 788 to 807 (20 residues), see Phobius details amino acids 813 to 834 (22 residues), see Phobius details TIGR01525: heavy metal translocating P-type ATPase" amino acids 252 to 833 (582 residues), 572.5 bits, see alignment E=1.7e-175 PF00122: E1-E2_ATPase" amino acids 331 to 420 (90 residues), 82.1 bits, see alignment E=2.2e-27 TIGR01494: HAD ATPase, P-type, family IC" amino acids 335 to 541 (207 residues), 105.5 bits, see alignment E=3.5e-34 amino acids 641 to 819 (179 residues), 120.4 bits, see alignment E=1e-38 PF00702: Hydrolase" amino acids 517 to 743 (227 residues), 117.2 bits, see alignment E=1.3e-37

Best Hits

KEGG orthology group: K01534, Cd2+/Zn2+-exporting ATPase [EC: 3.6.3.3 3.6.3.5] (inferred from 100% identity to dvm:DvMF_2066)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8DMQ3 at UniProt or InterPro

Protein Sequence (838 amino acids)

>DvMF_2066 heavy metal translocating P-type ATPase (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MTAFRIEEMDCANEVTVLRHALTPLVGNPDRLQFDVLSRRMRVDMDGLDLRPDDVVAAVA
RTGMRAAPEAAGRPGVVLGPLPSASHACTDGCCQPHQAGPIGHAGHGHDGCCGSAHAPVH
ASASASASAHAHAMPPRPAQIPALAGCPCCGGACDVPAPGDAPSGLLSLLPSGLTALWQR
QSSLLLCSLSGVALVAGIGVEWARTGSLLEVFAESGVPHAATLVLWLAAAVAGAWRVLPR
AVHAVRSLRPDMNLLMVTAVIGAAAIGQFFEGASVAFLFAVANQLESWSVDRARSAIAAL
LDISPSRALLLSRPGDVGGDVVAGMGGALTGTPVETAVENVPVGSRILIRAGDRVPLDGT
VAAGSSDIDQSPITGESMPVPKRAGEPVYAGTINGGGVLEVLTTRAASDTTLARILHMVE
AAQSRRARAVQWVDRFAAVYTPAMLAVAALVAVVPPLFFGGAWSAWVYEALVVLVIACPC
ALVISTPVSIVAGLTSAARNGVLVKGGSFLELPASLTAVAFDKTGTLTQGRPRVARVLPV
DGHPQVRDAASALRIAAALEGPSSHPLARAIVQHARQVPGAGLDDGATASDHRTLPGLGA
EGVVDGARWRIGNRRYFAQDGPQHGPSGGAESIGTDAAAAGSSVLLWNDAGLAAVMELED
DLRPDARAVLDDLRAAGLHRMVMLTGDNAATAARVAAACGVTDIRADLLPADKTAAVAAL
VAEGERVAMVGDGVNDAPALATAHLGIAMGGIGSDAAIETADITLMSDDLGKLPWLVRHS
RRTLGVIRQNIGFALGLKALFLGLAVFQVASLWMAIVADIGGSFLVIMNGLRLLRPKA