Protein Info for DvMF_1917 in Desulfovibrio vulgaris Miyazaki F

Annotation: heavy metal translocating P-type ATPase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 transmembrane" amino acids 21 to 37 (17 residues), see Phobius details amino acids 43 to 62 (20 residues), see Phobius details amino acids 244 to 263 (20 residues), see Phobius details amino acids 269 to 294 (26 residues), see Phobius details amino acids 577 to 601 (25 residues), see Phobius details amino acids 607 to 627 (21 residues), see Phobius details TIGR01525: heavy metal translocating P-type ATPase" amino acids 76 to 623 (548 residues), 520.9 bits, see alignment E=7.3e-160 TIGR01494: HAD ATPase, P-type, family IC" amino acids 102 to 598 (497 residues), 220.4 bits, see alignment E=5.3e-69 PF00122: E1-E2_ATPase" amino acids 127 to 298 (172 residues), 170.6 bits, see alignment E=2.5e-54 PF00702: Hydrolase" amino acids 317 to 535 (219 residues), 91.8 bits, see alignment E=7.7e-30

Best Hits

KEGG orthology group: K01534, Cd2+/Zn2+-exporting ATPase [EC: 3.6.3.3 3.6.3.5] (inferred from 100% identity to dvm:DvMF_1917)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8DPZ6 at UniProt or InterPro

Protein Sequence (650 amino acids)

>DvMF_1917 heavy metal translocating P-type ATPase (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MIGRFACPGSYRELISSRETLLCLLGGVLAAVSWVASLSGAPAWLAAALALTGAAINGLP
IVKGAVEGLMEKQVNVDELVSIALIASVAQGEYLSAAIVACIMKAGSLVEGFLSDAARRS
IKALASVTPDTATIIVPGGRERTVPASEVRVGQQLRVRPGERIPVDAVILSGITAVDESS
ITGEPLPRSCTTDDKVLAGTMNYNGVIVVEAQRVGEDTTIGKVVRLVEEAEAHNPRAARL
VDKYAQWFTPVVLACAAAAWAVSGESSRAVAVLIAGCPCALLMAAPTAAVAAVGRAARAG
IIVRGGQALEKVAAATLVLFDKTGTLTYGRPELDEVLPVPGMTEERLLALAAGAEGGGTH
PIARAIVAGAQARSVAPAAAEGAFTEVGVGVRATVDGHAVEVCGVTAEVEAELSQRAPGL
AQPLAALRSRGATALLVRVDTAPAGLLAVTDTLRSGARASVSGLRAAGLAHAGMLSGDHE
TAAARIAAEAGMDYWRAGLKPADKLASIRTQQQSGATVIFVGDGINDAPALAGADVGVAM
GGAGTDVALETADVALTHDDIGRLPFLVRLSRRAISLIKINIGLGVLFNALSILGSGYGL
LSPVMASVFHNVGSVIVVISSASLAFFDDGEPGQPACPAPAVPAAGGKAV