Protein Info for DvMF_1758 in Desulfovibrio vulgaris Miyazaki F

Annotation: UvrD/REP helicase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1244 PF27218: MJ0043_C" amino acids 338 to 399 (62 residues), 34.4 bits, see alignment 3.7e-12 PF00580: UvrD-helicase" amino acids 561 to 648 (88 residues), 84.4 bits, see alignment 2.9e-27 amino acids 700 to 786 (87 residues), 66.2 bits, see alignment 1e-21 PF13245: AAA_19" amino acids 564 to 783 (220 residues), 85.6 bits, see alignment E=8.9e-28 PF13361: UvrD_C" amino acids 804 to 938 (135 residues), 29 bits, see alignment E=2e-10 amino acids 1105 to 1199 (95 residues), 69.1 bits, see alignment 1.3e-22

Best Hits

KEGG orthology group: None (inferred from 100% identity to dvm:DvMF_1758)

Predicted SEED Role

"ATP-dependent DNA helicase pcrA (EC 3.6.1.-)" in subsystem DNA repair, bacterial UvrD and related helicases (EC 3.6.1.-)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.6.1.-

Use Curated BLAST to search for 3.6.1.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8DM59 at UniProt or InterPro

Protein Sequence (1244 amino acids)

>DvMF_1758 UvrD/REP helicase (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MQQFRADLHIHSRFSRATSGRLNARHLAAWARVKGLDVLGTGDFTHPRWRAELAEQLVPD
EASGLYRLRDPRGLDAELPEYAGKPLAGRTLFMLQAEISSIYKRGGKVRKVHNLVYVPDM
DAADRLSRRLAEVGNIESDGRPILGLDSRNLLEMVLETHPQAFLVPAHIWTPWFALFGSK
SGFDSVAECFGDLSSEIFAMETGLSSDPEMNWLWSELDRFALISNSDAHSGENLGREANL
FSGEIGYESILRSLKGQGIGGRFLGTLEFFPEEGKYHLDGHRKCGVVMEPRETRARGGLC
PVCGKPVTVGVLHRVVELADRETPIQSPGQQGYLSLIPLPEILGELLGVGAKSRKVAEQH
ARCVARFGSELNILQDVPEAELSRFWEPLGEGIARMRRREVLRQSGYDGEYGVVRVFTDK
ERASIQRRSVVGGLPLLEGMGVPAAPRADDGKTAPRATGKGRKGKGADRPSLLDGLGGQP
DAAAGAAGAVGAARSGLSDAAARPAPAAEPDFEFSPDPSAPGPYGASGLPDAPEADDGPP
PPAFAAFSAPRPPEGATVRFNPAQRRALAAGPQPVLVLAGPGTGKTRTLVGRVLHLVETG
IDARRILAVTFTRRAAAEMDERLATALGEDAPLPRTDTLHALAFEYWHRATPTPPVLLSE
EAARRVFAEANPDEPAQRLREAWEAIGVCREKMRSCLAEHAPLLARYTEQKAAWNLADYT
DLLEFWLDQMQNNIYASPWRHVLVDEIQDLSPLQLTLVRALAPRGGAGFFGIGDPDQSIY
GFRGAHGDVAAFLREAWPDLSVVALEENYRSSARILDFAGGLMQGRSACGPLRAARDMPG
ELHLFEAPTAEGEAAWIGEQIRGLIGATSHSLLDAGHGRTRRGTVLDEGGFSPGDIAVLV
RVKSLIPQLQRTLTRFGVPCAVPEAEAFWADQRVALILGAAGRMLGIGSTSSPAGPALPA
GLSHRRLVAEGVHPSLADRLGLDASPFPMHRGGDAADNAHGAPEAAAATGSPAVSGSPDG
SDGPEASGAAIDPAGGEAPLRPDAEIPARDTPHEVDCPPKVLARGPLGVAAYLRETPPFD
DLFWQSSAFRALSRAYDTHGGWAGLMNWISLQSELELVRRGSEKVQIMSLHAAKGLEFRA
VFLPALEDGIMPFAGAGTLTGKPQRDGASPDTRTDMDEERRLLYVGMTRASEGLFLSCAA
RRQLYGRELRLKPSRFLDDVPLEGLRRSMLVQHQKRKERQLSLM