Protein Info for DvMF_1713 in Desulfovibrio vulgaris Miyazaki F

Annotation: DNA polymerase I (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 872 PF02739: 5_3_exonuc_N" amino acids 14 to 173 (160 residues), 155.1 bits, see alignment E=2e-49 TIGR00593: DNA polymerase I" amino acids 14 to 871 (858 residues), 783.5 bits, see alignment E=1.8e-239 PF01367: 5_3_exonuc" amino acids 178 to 270 (93 residues), 89 bits, see alignment E=3.7e-29 PF00476: DNA_pol_A" amino acids 494 to 869 (376 residues), 478.7 bits, see alignment E=2e-147

Best Hits

KEGG orthology group: K02335, DNA polymerase I [EC: 2.7.7.7] (inferred from 100% identity to dvm:DvMF_1713)

Predicted SEED Role

"DNA polymerase I (EC 2.7.7.7)" in subsystem DNA-replication or DNA Repair Base Excision (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8DM15 at UniProt or InterPro

Protein Sequence (872 amino acids)

>DvMF_1713 DNA polymerase I (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MSLTQRLGLRGEPLWLMDGSAFIFRGFYAYQSMQRSDGFPTNALFIVTRILLRLLREERP
TNFCFVLDGKGPTFRHELFPPYKMQRAVTPEPLVQQLDPIKRMVRALGLPLVVSDGCEAD
DCIASLAARHRSERPVVIVGTDKDLKQCLHDNVVLWDPAAKEEKLVTLADFTAETGLAPA
RWPDFQAVIGDSSDNIPGIPGVGPKTAEKIFKDFGSLEDIRDRVGELPEKLRAKFEPHLE
TMFLYRQLTTLTTDACPEVTLPDLAVRPLDPAEAGAMLREFELRQLTRELSGMIENGSVT
SAPRSTSQVQASLFGDEGRRADPVNTCKDPGKLPDCEGVAAAVVPVFDNGAITAYAVAAG
DCESRYSGPVDALARHLSRAAQVAAPDVKHLLRTDPAWAGIDPARWFDLGLAAYLLNPEE
RDYGWPRLAARWGDELERSSGNPGLLALEMAGALSGRLAGAQLSRLMRTLEMPLIPVLAD
MEAAGIAVDLDAFAAFLREVQGELDRLTRDVYKAAGGEFNIRSSQQLAELLFGTLGLPTG
GKTKGGQTSTAQDVLEKLSGRHPVVDAILEFRKLEKLRSTYLEPLPRLVDGAGRIHTTFN
QLATATGRLSSSNPNLQNIPVRGDLGRRMRTCFTAAPGLRLVSADYSQVELRVLAHMSQD
PTLLAAFREGADIHSRTASLLYDVAQDQVSTDQRRNAKTINFGLIYGMGPQKLAQELRIP
LTEAKAFIERYFSKLQKLREFYDEAETTARELGYVTTMAGRRRLLPEIHSENTQLKSQAR
RQAINTLIQGSAADIIKLAMLAAHADPELRALNARLILQVHDELLLEVPADNAPAAGERL
AAIMSGVRPGGVALDVPLAVDWGQGENWGVAH