Protein Info for DvMF_1535 in Desulfovibrio vulgaris Miyazaki F

Annotation: Saccharopine dehydrogenase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03435: Sacchrp_dh_NADP
  • amino acids 4 to 137 (134 residues), 126.2 bits, E=1.1e-40
• PF16653: Sacchrp_dh_C
  • amino acids 141 to 389 (249 residues), 165.6 bits, E=2.5e-52

Best Hits

KEGG orthology group: K00290, saccharopine dehydrogenase (NAD+, L-lysine forming) [EC: 1.5.1.7] (inferred from 100% identity to dvm:DvMF_1535)

MetaCyc: 62% identical to carboxyspermidine dehydrogenase (Campylobacter jejuni jejuni 81116)
RXN-11566 [EC: 1.5.1.43]

Predicted SEED Role

"Carboxynorspermidine dehydrogenase"

MetaCyc Pathways

• spermidine biosynthesis II (3/4 steps found)
• norspermidine biosynthesis (2/6 steps found)
• superpathway of polyamine biosynthesis III (3/8 steps found)
• L-lysine biosynthesis IV (3/9 steps found)

KEGG Metabolic Maps

• Lysine biosynthesis
• Lysine degradation

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.5.1.43 or 1.5.1.7

Sequence Analysis Tools

See B8DLV7 at UniProt or InterPro

Protein Sequence (396 amino acids)

>DvMF_1535 Saccharopine dehydrogenase (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MARVLIIGAGGVGGVVVHKCAQVPSVFSEIMLASRTKSKCDALAADVKARTGRTIETARV
DADNVPELVALIRAYKPDMVLNIALPYQDLTIMDACLETGVHYLDTANYEPLDEAKFEYK
WQWAYQERFEKAGLMALLGSGFDPGVTNVFCAYVMKHLLDEVHVLDIIDCNAGDHGHPFA
TNFNPEINIREVTARGRYWERGEWVETDPLSWSMNYDFPDGIGPKKCFLMYHEELESLVL
NLKGLKRARFWMTFSDNYLNHLKVLENVGMTRIDEVEHDGKKIVPIQFLRALLPDPASLG
PRTKGKTCIGCLMQGVKDGKPKTVYIYNVCDHQECYREVGSQAISYTTGVPAMIGAMMMV
TGKWSGKGVYNMEQLDPDPFMDALNKHGLPWVVVEK