Protein Info for DvMF_1346 in Desulfovibrio vulgaris Miyazaki F

Annotation: Glu/Leu/Phe/Val dehydrogenase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF05088: Bac_GDH_CD
  • amino acids 404 to 531 (128 residues), 25.7 bits, E=4.3e-10
• PF00208: ELFV_dehydrog
  • amino acids 617 to 832 (216 residues), 117.3 bits, E=9.4e-38

Best Hits

KEGG orthology group: K00260, glutamate dehydrogenase [EC: 1.4.1.2] (inferred from 100% identity to dvm:DvMF_1346)

Predicted SEED Role

"Glu/Leu/Phe/Val dehydrogenase family protein"

MetaCyc Pathways

• L-glutamate degradation I (1/1 steps found)
• L-alanine degradation II (to D-lactate) (2/3 steps found)
• ethene biosynthesis IV (engineered) (1/3 steps found)
• 4-aminobutanoate degradation V (1/7 steps found)
• L-glutamate degradation XI (reductive Stickland reaction) (1/7 steps found)
• methylaspartate cycle (8/19 steps found)
• L-glutamate degradation V (via hydroxyglutarate) (1/10 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Glutamate metabolism
• Nitrogen metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.4.1.2

Sequence Analysis Tools

See B8DRK8 at UniProt or InterPro

Protein Sequence (1017 amino acids)

>DvMF_1346 Glu/Leu/Phe/Val dehydrogenase (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MAESHAKGVEEALSLVKGGLGGIADQVVPWFFANMPDYYLRTHSVTEQVHHLQAIISGRV
VTDNHAVRLASPDGRKITYISPSASRDLHGILAGLLGEHIETARIYTTADGQLGLNEFLL
APQPRAGSLRTAEGDDLFSAALDAMRASGELPETDMTAFAAFLAAANAEYVEKFDPVRAA
RHFRLLREIGGGDDTGLLIEQCSAPTIPAAPAASEATGGTGGVGTVLPAEPCDIRRETRI
VVAMRHPPATGLLLQIARIMRRLDITVHRSYADTFADESGETAIMSFYVSHKGDLILDDS
ALWQNLRKKLRLVKWFAPHELEILADEESWPIKRIMLLQAACGFAHVFLAKDNQWAFSTQ
NVVRIVLARRAETAALVDWFEARFDPTLGDREATARRLEADATDAVNAVADERERAVLLM
IQRFFRHVLRTNYFLDTIYGLSFRLDPEFLPPAYRYEGEELPFGIFFFHAPGGLGFHIRY
RDMARGGVRVVPTRTQEQFELESNRLYDEVKGLAYAQQVKNKDIPEGGAKAVILLGPLGD
VGLAVSSVINSLLDVVLPGQDTPALPGVVDYLGREEIIYCGPDENIQPAHIAWMVERARQ
RGYRWPSAFMSSKAGAGINHKQYGVTSIGVMVFAEEMLRHLGIDPFTQPFTVKLTGGPKG
DVAGNLMRLMFETYGDNARIVAVSDGHGGAWDPDGLDRAELLRLVDAQRSISAFDPARLR
GEGAWVAVSDTPEGVRRRNTLHNTAHADIFIPAGGRPDTINTRNWHDFFDRGGVPTARAV
IEGANLFVAPEARKRLAERGVLVVHGSSANKTGVICSSYEVLGGLVMTDEEFIAHKDRFV
AEVLDILRVRARDEARLLLAEIRRCDGCKALHEISVDVSLEMNAVADALYAALMARGEPV
EADPVLRQVLLGYLPPVLVERFPERIFERIPLRHQYALVAAHTASRIVYAEGAGWLAPLA
RQRDAESVARAWLREDGRIRDLIAAVSRSGLPEAGAVVHLLERGARKRATEEALGLE