Protein Info for DvMF_0976 in Desulfovibrio vulgaris Miyazaki F

Annotation: transketolase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00456: Transketolase_N
  • amino acids 4 to 334 (331 residues), 528.1 bits, E=2.1e-162
• TIGR00232: transketolase
  • amino acids 5 to 663 (659 residues), 946.8 bits, E=3.1e-289
• PF00676: E1_dh
  • amino acids 109 to 233 (125 residues), 22.1 bits, E=1.7e-08
• PF02779: Transket_pyr
  • amino acids 354 to 525 (172 residues), 181.7 bits, E=2.5e-57
• PF02780: Transketolase_C
  • amino acids 541 to 656 (116 residues), 59.3 bits, E=9.2e-20

Best Hits

Swiss-Prot: 65% identical to TKT1_VIBCH: Transketolase 1 (tkt1) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K00615, transketolase [EC: 2.2.1.1] (inferred from 100% identity to dvm:DvMF_0976)

MetaCyc: 66% identical to transketolase 1 (Escherichia coli K-12 substr. MG1655)
Transketolase. [EC: 2.2.1.1]; 2.2.1.1 [EC: 2.2.1.1]

Predicted SEED Role

"Transketolase (EC 2.2.1.1)" in subsystem Calvin-Benson cycle or Pentose phosphate pathway (EC 2.2.1.1)

MetaCyc Pathways

• Bifidobacterium shunt (13/15 steps found)
• pentose phosphate pathway (non-oxidative branch) II (6/6 steps found)
• pentose phosphate pathway (non-oxidative branch) I (5/5 steps found)
• formaldehyde assimilation III (dihydroxyacetone cycle) (10/12 steps found)
• pentose phosphate pathway (partial) (3/3 steps found)
• Rubisco shunt (8/10 steps found)
• pentose phosphate pathway (6/8 steps found)
• superpathway of glucose and xylose degradation (12/17 steps found)
• Calvin-Benson-Bassham cycle (9/13 steps found)
• formaldehyde assimilation II (assimilatory RuMP Cycle) (6/9 steps found)
• ethene biosynthesis V (engineered) (16/25 steps found)
• oxygenic photosynthesis (10/17 steps found)
• 1-butanol autotrophic biosynthesis (engineered) (14/27 steps found)
• photosynthetic 3-hydroxybutanoate biosynthesis (engineered) (13/26 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of ansamycins
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Carbon fixation in photosynthetic organisms
• Pentose phosphate pathway

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.2.1.1

Sequence Analysis Tools

See B8DPM4 at UniProt or InterPro

Protein Sequence (664 amino acids)

>DvMF_0976 transketolase (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MPSRKELANAIRVLSMDAVEKAKSGHPGAPMGMADIAEVLWNDSLKHNPANPKWADRDRF
VLSNGHGSMLIYALLHLSGYDVSMDDIRNFRQLHSKTPGHPEYGITPGVETTTGPLGQGI
ATAVGMAMAERLMAQQFNRPGYDVVDHATYVFLGDGCMMEGISHEACSLAGTLGLGKLTA
FYDDNGISIDGDIAGWFADDTPARFEAYGWHVVRNVDGHDGEAIAAALKAARAVPGKPSL
ICCKTRIGQGAPTKAGSHNCHGSPLGAAEIAAAREGMNWPHPPFEIPADIYAGWDARPRG
TAAETAWNDLFARYRAAHPELAAEFERRMAGDLPADWQAGVAAALAATDGARETLATRIA
SRNALNAVAPLLPEMIGGSADLTGSVGTWHKNSKLVTPGDWSGNYISYGVREFAMGAIMN
GMALHGGFLPYAGTFLIFSDYAKNAIRLSALMGARVVWVLTHDSIGVGEDGPTHQPVEQL
AGLRLTPNVQVWRPCDTVETLSAWKAAAECATGPTCISLTRQDVPFVERTAEQRANIMRG
GYVLRDCAGTPESIIMATGSEVQLALAAADALAAKGRKVRVVSMPSSTQFDRQDAAYRES
VLPSAVRARVAVEAATVDGWWKYLGLDGKAVGMTGFGESAPGKVLFEYFGITTEKVIEAV
ESLI