Protein Info for DvMF_0816 in Desulfovibrio vulgaris Miyazaki F

Annotation: Acetyl-CoA carboxylase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

KEGG orthology group: K01962, acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC: 6.4.1.2] K01963, acetyl-CoA carboxylase carboxyl transferase subunit beta [EC: 6.4.1.2] (inferred from 100% identity to dvm:DvMF_0816)

Predicted SEED Role

"Acetyl-coenzyme A carboxyl transferase alpha chain (EC 6.4.1.2) / Acetyl-coenzyme A carboxyl transferase beta chain (EC 6.4.1.2)" in subsystem Fatty Acid Biosynthesis FASII (EC 6.4.1.2)

MetaCyc Pathways

fatty acid biosynthesis initiation (type I) (1/3 steps found)
propanoyl CoA degradation I (1/3 steps found)
2-oxobutanoate degradation I (1/4 steps found)
jadomycin biosynthesis (3/9 steps found)
anaerobic energy metabolism (invertebrates, mitochondrial) (3/10 steps found)
3-hydroxypropanoate cycle (5/13 steps found)
superpathway of anaerobic energy metabolism (invertebrates) (7/17 steps found)
methylaspartate cycle (8/19 steps found)
superpathway of L-methionine salvage and degradation (5/16 steps found)
3-hydroxypropanoate/4-hydroxybutanate cycle (5/18 steps found)
superpathway of the 3-hydroxypropanoate cycle (5/18 steps found)
superpathway of mycolate biosynthesis (18/239 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.4.1.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8DL69 at UniProt or InterPro

Protein Sequence (754 amino acids)

>DvMF_0816 Acetyl-CoA carboxylase (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MDTEKRTQHLAERLGYIRDVFGGKHNENIALLDSKLQEFNLRLSEGAISDENAALTTLED
LFDFVERKLEAELTPMDKVRIVRHPQRICLRDILENVYDNYTEIGGKDEHSIDPSMLIAR
AYITRRSGKKTINQPVLVIGQEKGHGEEFRNGGSVKPWGNAKALQYMKVAETEGIPIHTY
VFTPGSYPVEDYPGAAQQIARNLYEMAGLRVPVIAVFSEGGSGGAEAIGLSDRRLMLSHG
YYSVISPEGAAAIEGRLRHGQRAAPELIEKCAQQLRITAEDNLRMGYIDHVVTEPPLGAR
PYHYDFFRGLRQEIIRATDEVILGVKGFAPFRAMVLRRRRGKAETMDLDNMYVRWSLSSS
AKDRLVARRHRKFNRLARNAARDRRPVLRKLSNMGWDAWWDIYSYFKYDLLRKHQQKIAY
LMEEVEAEAQVLMEKVAAPWRKITCALPGGACQSSEQTERELTTLSDWDEEGQRSGNWSY
VSPRAKEDRAITCPNAGSHGCLDLWAPDLFGEFAGVCTYCGHHFPMEYQWYLHNVFDEGS
IFEFNAEIEAGNPLGFEGFDVKLEQAKKQTGLKSGCVTFEARIDNVKLVVAMLVAPFRGG
SVGAAEGEKFVQAAERAKKKRYPFLAYVHGTAGIRIQEGTNGVIQMPRCTMAVRRYIEAG
GLYLVLYDTNSYAGPLASFLGCSPYQFSIRSANIGFAGPGVIKETTGVDIPPDYHRAYRA
LSRGHIQGIWDRRDARMNLKQALLTMGGRNLYYR