Protein Info for DvMF_0616 in Desulfovibrio vulgaris Miyazaki F

Annotation: signal transduction histidine kinase, nitrogen specific, NtrB (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 908 transmembrane" amino acids 21 to 44 (24 residues), see Phobius details amino acids 201 to 227 (27 residues), see Phobius details PF08269: dCache_2" amino acids 47 to 195 (149 residues), 68.6 bits, see alignment E=2.5e-22 PF17200: sCache_2" amino acids 51 to 196 (146 residues), 87.1 bits, see alignment E=5.4e-28 TIGR00229: PAS domain S-box protein" amino acids 252 to 371 (120 residues), 47.4 bits, see alignment E=9.8e-17 amino acids 519 to 575 (57 residues), 23.7 bits, see alignment 2.2e-09 PF00989: PAS" amino acids 254 to 307 (54 residues), 23 bits, see alignment 3e-08 amino acids 521 to 574 (54 residues), 29.4 bits, see alignment 3.2e-10 PF08447: PAS_3" amino acids 276 to 354 (79 residues), 27.5 bits, see alignment E=1.4e-09 PF08448: PAS_4" amino acids 382 to 492 (111 residues), 33.1 bits, see alignment E=2.6e-11 amino acids 526 to 643 (118 residues), 24.4 bits, see alignment E=1.3e-08 PF13188: PAS_8" amino acids 521 to 573 (53 residues), 31.6 bits, see alignment 5.1e-11 PF00512: HisKA" amino acids 660 to 744 (85 residues), 29.6 bits, see alignment E=2.6e-10 PF02518: HATPase_c" amino acids 798 to 907 (110 residues), 75 bits, see alignment E=2.9e-24

Best Hits

KEGG orthology group: None (inferred from 100% identity to dvm:DvMF_0616)

Predicted SEED Role

"sensory box histidine kinase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8DJX7 at UniProt or InterPro

Protein Sequence (908 amino acids)

>DvMF_0616 signal transduction histidine kinase, nitrogen specific, NtrB (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MNAIPPRTLASLLRSPPVRRLWLLLVLACAVFTLFLLHAVHTFWETAETYRRSHLREMVL
LARNQVQPVLDELAAGAYGRDHALVLVRERVRTMIFNDTHGPNYIFMSGYDGTVLVQPYN
RLMEGRSGLDLRDANGVAIIVELIRTAQANPDGGYFSYLYTPPDSSEPEEKLSFVLPIPE
LACYIGTGSYLGDVHAGERRYILATAALAVTVFVLLGLTFVTALGALARRGAELEREVEE
RKATEQRLAAAELKYRSIFQNAQEGIAVIQDGLLRFVNPRIGEILRRPAEELVGTPFTDH
LHPADRPVARDRYIRRLNGAPLGTYPPVRICAPDGERWVFGTGVLLEWDGRPAVLVMLTD
ITDLKKAEQALHAREQQFRAVLTQAPFAMALLHPDGTLREANAEWLALHGLAEATGNPAV
YTLGQDRYVLHAGLHGLAQAALAGEAIATEPLEFPPDATPDGQTRWMALRLYPVGGAPGK
PDAVAFNLNDLTVLMESERERQALLADLSRANRALSRAQRHLKGVLDAMPSAIVVADAAD
RVVLWNPAAERRFGVAAPSAHGRPLVEVAPELARHLPRLHAARRGGAAVPPERVVTPVEL
PAGSQPGTLSRESRRVEDVTAIPLETGEEMWGILRLDDVSERAAMEDLMVQAEKMASVGG
LAAGMAHEINNPLGGILQGVQNLRRRLLDDLPANRAAAERQGMDFDRIAAYAEERRIGGL
LDGIRESGERATRIVANMLTFSRRSDPSRVPVQINDLLERTLELAVTDYSLARNYDFKRI
TVVRRYDPQLPPVRCSASEMEQVFLNLFKNAAQALALRDDGPPPVLTLTTAVEVAHLRIE
VADNGPGMSPELRRRAFEPFFTTREAGAGTGLGLSVAYFIVVTNHKGTITIEEAPEGGAV
VVVRLPLA