Protein Info for DvMF_0514 in Desulfovibrio vulgaris Miyazaki F

Annotation: phosphonoacetaldehyde hydrolase (RefSeq)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 280 TIGR01422: phosphonoacetaldehyde hydrolase" amino acids 14 to 264 (251 residues), 310.2 bits, see alignment E=9.6e-97 PF00702: Hydrolase" amino acids 14 to 206 (193 residues), 51.1 bits, see alignment E=3.5e-17 PF13419: HAD_2" amino acids 39 to 212 (174 residues), 30.4 bits, see alignment E=6.3e-11 TIGR01549: HAD hydrolase, family IA, variant 1" amino acids 149 to 206 (58 residues), 23.4 bits, see alignment E=6.7e-09 PF13242: Hydrolase_like" amino acids 166 to 218 (53 residues), 22.5 bits, see alignment E=1.3e-08

Best Hits

Swiss-Prot: 100% identical to PHNX_DESVM: Phosphonoacetaldehyde hydrolase (phnX) from Desulfovibrio vulgaris (strain Miyazaki F / DSM 19637)

KEGG orthology group: K05306, phosphonoacetaldehyde hydrolase [EC: 3.11.1.1] (inferred from 100% identity to dvm:DvMF_0514)

MetaCyc: 40% identical to phosphonoacetaldehyde hydrolase subunit (Pseudomonas aeruginosa)
Phosphonoacetaldehyde hydrolase. [EC: 3.11.1.1]

Predicted SEED Role

"Phosphonoacetaldehyde hydrolase (EC 3.11.1.1)" in subsystem Phosphonate metabolism (EC 3.11.1.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.11.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8DKP2 at UniProt or InterPro

Protein Sequence (280 amino acids)

>DvMF_0514 phosphonoacetaldehyde hydrolase (RefSeq) (Desulfovibrio vulgaris Miyazaki F)
MKPFLRTRVYDGPVRAVVLDWAGTAVDHGCLGPAAVFVQAFALHGVEVAVSEAREPMGSE
KREHVRRMLAMDSVAARWRAVHGHVPHEADVDAVYRDVEPLMLQTIAAHAVPVPGLAEFV
DRVRGRGMGLGSCTGYTGPMMEVLVPEAARRGYSPDVVVHASEVPAGRPYPWMCYLNAMR
LGVHPMESMVKIGDTVADMHEARNAGMWTVGVVRTGNDVGLSEVDAARMPPDQLAARMTV
AAARLREAGAHYVVDSIADCFSVIKAIEARLARGDTPYPA